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Prof Adrienne Flanagan
Appointment
  • Professor of Musculo- Skeletal Pathology
  • Research Department of Pathology
  • Cancer Institute
  • Faculty of Medical Sciences
Research Groups
Research Themes
Research Summary
Our research programme focuses on identifying the genetic alterations involved in the development and progression of bone and soft tissue tumours. Correlation of these abnormalities with the histopathology improves diagnostic accuracy, allows sub-classification of neoplastic disease and helps to predict therapy, and outcome / survival. This approach has allowed us identify the molecule, brachyury, in a rare neoplasm, chordoma, which is now employed universally in the diagnosis of this tumour. We have demonstrated that GNAS1 mutations commonly occur in myxomas (benign tumour) which helps distinguish this from other tumours which are malignant. The group has strong ties with The Wellcome Trust Sanger Centre where genome-wide analyses are being performed on chordoma. We also are collaborating with a group in the National Human Genome Research Institute, National Institituteof Health, Washington, USA. The research benefits from having access to one of the largest subspecialty orthopaedics referral centres in Europe, The Royal National Orthopaedic Hospital.
Teaching Summary
Undergraduate: cancer – pathology; bone and joint disease. Postgraduate: Basic sciences MSc in Orthopaedics, FRCPath Oxford Pathology Course; Advanced Histopathology Course in the East of England Deanery; Thames Deanery Bone and Soft Tissue Teaching for SHOs and SpRs; SpR training in Bone and Soft Tissue, Leeds; World Association of Societies of Pathology and Laboratory Medicine (WASPaLM), Penang 2008 – International Update on bone tumours; Association of Societies of Pathology and Laboratory Medicine (WASPaLM), Update Chandigarh 2010 – International Update on soft tissue tumours; “Notable gene expression: brachyury, mutations.” National Institutes of Health (NIH) meeting, “The First and Second International Chordoma Research Workshop.” Invitation only meeting. Plenary lecture May 2007 & 2008. Molecular genetic events in fibro-osseous and osteoclast-rich lesions of the jaw. The 14th International Congress of Oral Pathology and Medicine. San Francisco. June 2008. Plenary lecture and Seminar. ‘Crucial molecular genetic events in chordoma – plenary lectury’ 43rd Annual Musculoskeletal Tumor Meeting of the Japanese Orthopaedic Association, Shinjuku, Tokyo, Japan, June 2010.
Academic Background
1990 PhD Doctor of Philosophy University of London
1981 MB Bachelor of Medicine Royal College of Surgeons in Ireland
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