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Prof Adrienne Flanagan
202
Rockefeller Building
21 University Street
London
London
WC1E 6DE
Tel: 020 7679 6020
Appointment
  • Professor of Musculo- Skeletal Pathology
  • Research Department of Pathology
  • Cancer Institute
  • Faculty of Medical Sciences
Biography

Adrienne received her medical degree from the Royal College of Surgeons in Ireland and undertook her PhD at the University of London in 1990 while she was a Medical Research Council Training Fellow at St George's Hospital Medical School in London. She became a senior lecturer and honorary consultant pathologist at Imperial College London, and later moved to University College London, and now practices clinical pathology at the Royal National Orthopaedic Hospital.  Adrienne was elected as Professor of Musculoskeletal Pathology at UCL’s Cancer Institute in 2004.  Adrienne is the Meeting Secretary of Pathological Society of Great Britain and Ireland, and a trustee or member of various committees including the Sarcoma UK Research Advisory Committee, The Jean Shanks Foundation, The Chordoma Foundation (USA) and the National Quality Assurance Advisory Panel of the Royal College of Pathology. Her research interests focus on reclassifying bone and soft tissue tumours using molecular signatures which she then translates into clinical practice, and uses for stratifying patients for treatment. She is the co-lead of the International Cancer Genome Consortium bone tumour project.

Research Groups
Research Themes
Research Summary

Our research programme focuses on identifying the genetic alterations involved in the development and progression of bone and soft tissue tumours. Correlation of these abnormalities with the histopathology improves diagnostic accuracy, allows sub-classification of neoplastic disease and helps to predict therapy, and outcome / survival. This approach has allowed us identify the molecule, brachyury, in a rare neoplasm, chordoma, which is now employed universally in the diagnosis of this tumour. We have demonstrated that GNAS1 mutations commonly occur in myxomas (benign tumour) which helps distinguish this from other tumours which are malignant. The group has strong ties with The Wellcome Trust Sanger Centre where genome-wide analyses are being performed on chordoma. We also are collaborating with a group in the National Human Genome Research Institute, National Institituteof Health, Washington, USA. The research benefits from having access to one of the largest subspecialty orthopaedics referral centres in Europe, The Royal National Orthopaedic Hospital.

Teaching Summary

Undergraduate: cancer – pathology; bone and joint disease. Postgraduate: Basic sciences MSc in Orthopaedics, FRCPath Oxford Pathology Course; Advanced Histopathology Course in the East of England Deanery; Thames Deanery Bone and Soft Tissue Teaching for SHOs and SpRs; SpR training in Bone and Soft Tissue, Leeds; World Association of Societies of Pathology and Laboratory Medicine (WASPaLM), Penang 2008 – International Update on bone tumours; Association of Societies of Pathology and Laboratory Medicine (WASPaLM), Update Chandigarh 2010 – International Update on soft tissue tumours; “Notable gene expression: brachyury, mutations.” National Institutes of Health (NIH) meeting, “The First and Second International Chordoma Research Workshop.” Invitation only meeting. Plenary lecture May 2007 & 2008. Molecular genetic events in fibro-osseous and osteoclast-rich lesions of the jaw. The 14th International Congress of Oral Pathology and Medicine. San Francisco. June 2008. Plenary lecture and Seminar. ‘Crucial molecular genetic events in chordoma – plenary lectury’ 43rd Annual Musculoskeletal Tumor Meeting of the Japanese Orthopaedic Association, Shinjuku, Tokyo, Japan, June 2010.

Appointments
  Consultant histopathologist Histopathology Royal National Orthopaedic Hospital, United Kingdom
  Head of Department of Pathology Pathology UCL Cancer Institute, United Kingdom
Academic Background
1990 PhD Doctor of Philosophy – Medicine University of London
1981 MB Bachelor of Medicine – Pathology Royal College of Surgeons in Ireland
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