Help Desk: http://www.ucl.ac.uk/ras/portico/helpdesk
- Professor of RNA Biology
- Structural & Molecular Biology
- Div of Biosciences
- Faculty of Life Sciences
Andres Ramos has a PhD from
We study the structural and molecular foundations of RNA metabolism in eukaryotes. We focus on the mechanisms that regulate miRNA biogenesis, and mRNA transport and localised translation - and on the errors in these mechanisms that are linked to cancer and neurological diseases.
RNA-binding proteins act on multiple mRNA targets at different steps in the mRNA life cycle, and regulate the synthesis and function of non-coding regulatory RNAs. We analyse how RNA-binding proteins select their targets from the extensive cellular RNA pool, and how they regulate RNA processing and transport by interacting with their associated machineries. By combining structural and biophysical data with functional cell-based assays, we build a mechanistic understanding of these regulatory processes and how to manipulate them.