Help Desk: http://www.ucl.ac.uk/ras/portico/helpdesk
- Professor of RNA Biology
- Structural & Molecular Biology
- Div of Biosciences
- Faculty of Life Sciences
Andres Ramos has a PhD from
We study the structural and molecular foundations of RNA metabolism in eukaryotes. We focus on the mechanisms that regulate mRNA and miRNA biogenesis and mRNA transport and localised translation - and on the errors in these mechanisms that are linked to cancer and neurological diseases.
Nucleic acid binding proteins act on multiple targets at different steps in the mRNA life cycle, and regulate the synthesis and function of non-coding regulatory RNAs. We analyse how these nucleic acid binding proteins select their targets from the extensive cellular pool, and how they regulate RNA biogenesis and transport by interacting with their associated machineries. By combining structural and biophysical data with functional cell-based assays, we build a mechanistic understanding of these regulatory processes and how to manipulate them.