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- Professor of RNA Biology
- Structural & Molecular Biology
- Div of Biosciences
- Faculty of Life Sciences
Andres Ramos has a PhD from
Selected research papers:
Collins, K., Oregioni, A., Robertson L.E., Kelly, G., and Ramos, A.* (2015). Protein-RNA specificity by high-throughput principal component analysis of NMR spectra. Nucleic Acid Res. doi:10.1093/nar/gku1372
Nicastro, G., García-Mayoral, MF., Hollingworth, D., Kelly, G., Martin, S.R., Briata, P., Gherzi, R. and Ramos, A.* (2012). Non-canonical Guanine recognition mediates KSRP regulation of Let-7 biogenesis. Nat. Struct. Mol. Biol. 19, 1282-1286. PMID:23142982
Hollingworth, D., Candel, A.M., Nicastro, G., Martin, S.R., Briata, P., Gherzi, R. and Ramos, A.* (2012). KH domains with impaired nucleic acid binding as a tool for functional analysis. Nucleic Acid Res. 40, 6873-6886. PMID:22547390
Cukier, C.D., Hollingworth, D., Kelly, G., Martin, S.R., Díaz-Moreno, I., and Ramos, A.* (2010). Molecular basis of FIR-mediated c-myc transcriptional control. Nat. Struct. Mol. Biol. 17, 1058-1064. PMID:20711187
Díaz-Moreno, I., Hollingworth, D., Frenkiel, T.A., Kelly, G., Martin, S.R., Howell, S., García-Mayoral, MF., Gherzi., R., Briata P. and Ramos, A.* (2009). Phosphorylation-mediated unfolding of a KH domain regulates KSRP localization via 14-3-3 binding. Nat. Struct. Mol. Biol. 16, 238-246. PMID:19198587
Trabucchi, M., Briata, P., Garcia-Mayoral, MF., Haase A., Filipowicz, W ., Ramos, A.*, Gherzi, R. and Rosenfeld, G.M. (2009). The RNA binding protein KSRP promotes the biogenesis of a subset of miRNAs. Nature 459, 1010-1014. PMID:19458619
Beuth, B., Garcia-Mayoral, MF., Taylor, I.A. and Ramos, A.* (2007). Scaffold Independent Analysis of RNA-protein interactions: the Nova-1 KH3-RNA complex. J. Am. Chem. Soc., 129, 10205-10210. PMID:17655233
Noble, C., Hollingworth, D., Martin, S.R., Ennis-Adeniran, V., Smerdon, S., Kelly, G., Taylor, I.A. and Ramos, A.* (2005). Key features of the interaction between Pcf11 CID and RNA polymerase II CTD. Nat. Struct. Mol. Biol. 12, 144-151. PMID:15665873
* Corresponding author
We study the structural
and molecular foundations of RNA metabolism in eukaryotes. We focus
on regulatory mechanisms that play a key role in cancer and
RNA metabolism is controlled by a network of protein-RNA interactions. We analyze how nucleic acid binding proteins select their RNA targets from the cellular pool and how they then work together with the core cellular machines to regulate specific pathways. We develop novel NMR methodologies to look at structure and specificity in these large, transient protein-RNA complexes. By combining structural and biophysical data with functional cell-based assays and genome-wide screens, we aim to build mechanistic models of regulation that allow the manipulation of individual regulatory pathways.
Key research questions:
How is the biogenesis of miRNAs regulated in a cell and stage specific fashion?
How is the translation of specific mRNAs restricted in space and time?
How do RNA binding proteins recognize a diverse ensemble of cellular targets, and how is this recognition regulated?