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Prof Andres Ramos
514a
Research Department of Structural & Molecular Biology
Darwin Building, Gower St
london
WC1E 6BT
Tel: 020 76791565
Fax: 020 76797193
Appointment
  • Professor of RNA Biology
  • Structural & Molecular Biology
  • Div of Biosciences
  • Faculty of Life Sciences
Biography

Andres Ramos has a PhD from Cambridge University and the Laboratory of Molecular Biology (LMB) and has undergone post-doctoral training at the MRC National Institute for Medical Research, in London. In 2004 he established his independent research group at NIMR and was tenured in December 2009. Since October 2013 he is Professor of RNA Biology in the Research Department of Structural and Molecular Biology at UCL.

Research Themes
Research Summary

We study the structural and molecular foundations of RNA metabolism in eukaryotes. We focus on the mechanisms that regulate mRNA and miRNA biogenesis and mRNA transport and localised translation - and on the errors in these mechanisms that are linked to cancer and neurological diseases.

Nucleic acid binding proteins act on multiple targets at different steps in the mRNA life cycle, and regulate the synthesis and function of non-coding regulatory RNAs. We analyse how these nucleic acid binding proteins select their targets from the extensive cellular pool, and how they regulate RNA biogenesis and transport by interacting with their associated machineries. By combining structural and biophysical data with functional cell-based assays, we build a mechanistic understanding of these regulatory processes and how to manipulate them.

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