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- Professor of Infectious Diseases and International Health
- Research Department of Infection
- Div of Infection & Immunity
- Faculty of Medical Sciences
1.CLINICAL TRIALS FOR EVALUATION NEW DIAGNOSTICS, DRUGS, TREATMENT AND PROPHYLACTICS: Professor Zumla has created major international multi-country collaborations between academia, health care providers and industry for the conduct of multi-centre GLP/GCP clinical trials, the results of which have changed global practice. Seven of 11 randomised clinical trials have been completed. A phase 1 trial of autologous bone-marrow-derived stem cell transfusions for treatment of MDR-TB in Belarus in collaboration with Professor Maeurer of Karolinska Institutet (PI) has been completed. A phase II trial is underway.
2. PATHOGENESIS STUDIES AND EPIDEMIOLOGICAL STUDIES: In 2002, a large autopsy study of 264 Zambian children undertaken by Prof.Zumla and colleagues yeilded high impact data on pathogenesis of killer respiratory tract infections. Sentinel epidemiological and clinical studies have shown the emergence of extensively drug resistant TB. Several autopsy and molecular studies of adults and children are ongoing.
3. RESEARCH INTO THE EPIDEMIOLOGY, DIAGNOSIS, TREATMENT AND PREVENTION OF KILLER RESPIRATORY INFECTIONS ESP TB, TB/HIV AND MERS-COV: Laboratory and translational clinical research on longitudinal cohorts of patients is leading to development and evaluation of rapid diagnostics (urine, sputum and blood based) and biomarkers for diagnosis, response to treatment, cure and relapse. Novel biomarkers of cytokine ratios, urine and filter paper based TB diagnostics tests have been developed and current work focusses on development of new and novel rapid TB diagnostic technology, in inpatient settings in paediatric and adult wards. These data are novel show a huge clinical load of undiagnosed sub-clinical TB leading to new screening diagnostic algorithms and now call for more pro-active screening for TB at all points of care.
UK/UCL BASED R&D:
1.TB IN LONDON: Professor Zumla pioneered The London TB Link R&D Project at a time when TB was thought not to be a problem in London. His group’s data focussed UK governmental attention to the growing TB problem in London in immigrants, homeless and the elderly Research and advocacy activities on TB in has led to recognition of TB by the UK government as an important health issue with improved NHS TB services.
2.DEVELOPMENT OF RAPID DIAGNOSTIC TESTS FOR SEPSIS: Professor Zumla currently leads as PI several clinical translational TB projects including a 6 million euros EU-FW7 project on development of rapid diagnostic platforms for range respiratory tract pathogens linking industrial partners from France and Finland with hospitals in the UK and France. This will take forward the aim of developing point of care rapid diagnostics using multiplex platforms ‘sample in – answer out’’ within 1 hour for the diagnosis (including antibiotic resistance genes screening) of respiratory tract infections (RTIs) caused by a wide range of bacterial, viral and fungal pathogens from one sputum sample. Professor Zumla’s vision is to see this technology be powered by solar power so that it could be used at points of care in resource-poor tropical countries for accurate rapid diagnosis of RTI’s.
1. Undergraduate Medical students: Infectious diseases/microbiology/tropical Medicine/Clinical bedside 2. Supervision of PhD students 3. Supervision of postdoctoral scientists
2. Visitng Professor to the several Institutions eg: Institute of Child Health, London; University of Zambia School of Medicine;Lusaka, Zambia; University of Cape Town, South Africa; Liverpool School of Medicine; University of Amsterdam; Karolinska Institutet.
3. External examiner for MSc and PhDs to several national and international universities.
4. BOOKS AND SPECIALIST JOURNAL VOLUMES:
A) TEXTBOOKS: Editor of 18 textbooks including MRCP Part 1, MRCP Part 2, Granulomatous Disorders; Return of the White Plague; Clinics in Chest Medicine -Tuberculosis; Infectious Diseases Clinics of North America vols x 3; the global 'classics a) Manson's Tropical Diseases,21st and 22nd editions b) Tuberculosis- a comprehensive Clinical Reference.
B) JOURNALS: Several eg: a. Lancet Infectious Diseases b. Current Opinion in Pulmonary Medicine, c. Editor, COPM Infectious Diseases volume, d. IDClinics North America
5. GLOBAL HEALTH CURRICULUM DEVELOPMENT: Founder member with Prof J.Yudkin, of IHMEC-Intl Health Medical Education Centre at UCL-SSMs in international health, intercalated BSC in International health at UCL
6. TEACHING THROUGH HIGH PROFILE JOURNAL THEME SERIES: 1. Lead 'guru' Lancet TB Theme series (2010), 2. Chief Guest Editor Journal of Infectious diseases volume on TB, TB/HIV/AIDS-unanswered questions and controversies 2012, 3. Guest editor, Lancet Infectious Diseases series on Tuberculosis (2013), 4. Guest Editor Lancet Resp Med Series (2014), 5. Lancet Mass Gatherings Medicine Series (2014).
|1987||PhD||Doctor of Philosophy||London School of Hygiene and Tropical Medicine|
|1984||MRCP||Member of the Royal College of Physicians||Royal College of Physicians|
|1981||MSc||Master of Science||University of London|
|1979||MB.ChB||Bachelor of Medicine, Bachelor of Surgery||To be updated|
|1976||BSc||Bachelor of Science||To be updated|