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Prof Claudia Wheeler-Kingshott
603
Russell Square House
London
WC1N 3BG
Tel: +44 (0)20 31087448
Appointment
  • Professor in Magnetic Resonance Physics
  • Neuroinflammation
  • Institute of Neurology
  • Faculty of Brain Sciences
Biography

nerve


I was born in Milan (Italy) in 1969, moved to a little village on the Italian Riviera at 10, called Bonassola, studied Physics at the University of Pavia and then came to the UK with a COMETT grant for graduated students.

I did my PhD in sequence development under the supervision of Simon Doran and David Gilfoyle on developing fast imaging sequences (BURST) collaborating with the University of Lyon (France), the Nathan Kline Institute (USA) and the Institute of Child Health (ICH).

I join the NMR Research Unit at the UCL Institute of Neurology in January 1999 as a postdoctoral fellow where now I am University Reader in MR Physics and lead the MRI development on the 3T scanner dedicated to research in MS.

I love my work especially for the translational aspect of it between technical development and clinical applications. I love the international group of people I work with and haveing a group of 5 PostDocs and as many PhD students in collaboration with colleagues from other Departments including Computer Sciences and Brain Repair and Rehabilitation.


Research Themes
Research Summary

Research interests:

  • Develoment of quantitative MR imaging biomarkers in the Central Nervous System;
  • Structural and functional characterization of complex systems;
  • Applications to disease (e.g. Multiple Sclerosis and spinal cord injury);
  • Multi-nuclear spectroscopy and imaging.

Research topics:

  • Advanced Diffusion Imaging with applications to spinal cord, optic nerve and brain;
  • Brain and spinal cord Spectroscopy and Chemical Shift Imaging;
  • Brain neuroscience: connectomics and the cerebellum;
  • Magnetisation Transfer in the brain, optic nerve and spinal cord;
  • Cortical measurements, including thickness and complexity;
  • Relaxometry in the central nervous system;
  • Functional imaging in the brain and spinal cord;
  • Sodium imaging and spectroscopy;
  • Phosphorus spectroscopy.

Teaching Summary

Courses I am involved:

At the UCL Institute of Neurology I am involved with postgraduate training through teh MSC in Advanced Neuroimaging and PhD training, also supervising a number of students.

I have organised several teaching courses for the International Society for Magnetic Resonance in Medicine (ISMRM) on diffusion imaging and quantitative imaging biomarkers.

Examples of funding for projects I am leading:

Engineering and Physicsal Sciences Research Council (EPSRC): “Axon and Myelin damage assessed using diffusion imaging: from mathematical models to clinical applications.” Ref. EP/I027084/1. Principal Investigator: Dr C. Wheeler-Kingshott. Co-applicants: Prof. D Alexander, Dr. O Ciccarelli, Dr. D Thomas (£815,568.64 FEC, EPSRC contribution £652,454.91). (From 01/06/2011 to 31/05/2014).


International Spinal Research Trust, Nathalie Rose-Barr (NRB) PhD studentship entitled: “Development of MRI modalities to assess spinal cord (SC) function and structure”. Ref. NRB101. Principal Investigator: Dr C. Wheeler-Kingshott. Co-applicants: Dr A. Toosy (£93,018). (From 02/11/2010 to 01/11/2013).


MS Society of Great Britain and Northern Ireland Programme Grant entitled: “Translating new magnetic resonance imaging insights in to treatment options and clinical trial design in multiple sclerosis” Principal Investigators: Prof D.H. Miller (lead), Prof. A.J. Thompson, Prof. M. Ron, Prof. T. Yousry. Co-applicants: Dr C. Wheeler-Kingshott, Dr O. Ciccarelli, Dr K. Schmierer. (£2,544,384). (From 01/01/2009 to 31/12/2012).


UCLH/UCL Comprehensive Biomedical Research Centre (CBRC) New Initiative Capacity Building Application. “Translating new MRI techniques and proof-of-concept trials to develop neuroprotective and neuroreparative treatments to prevent and reverse disability in multiple sclerosis”. Principal Investigator: Prof D. Miller. Co-applicants: Dr R. Kapoor, Prof A. J. Thompson, Prof K. Smith, Dr S. Cano, Dr C. Wheeler-Kingshott. (£498,256) (From 01/01/2009 to 31/12/2012).


Novartis. “A double-blind, randomized, multicentre, placebo-controlled, parallel-group study comparing the efficacy and safety of 1.25mg FTY720 administered orally once daily versus placebo in patients with primary progressive multiple sclerosis”. Principal Investigator: Prof D. Miller. Co-applicants: Dr C. Wheeler-Kingshott and Mr D. MacManus. (£2,460,840) (From 19/11/2007 to 18/11/2014).


MS Society Project grant  “Grey matter abnormalities on 3 Tesla MRI and their functional effects in multiple sclerosis”. Principal Investigator: D H Miller Co-applicants: X Golay, CWK Wheeler-Kingshott, M Ron, T Yousry (£391,533) (From 09-2009 to 08-2012)

Appointments
01-OCT-2015 Professor of MR Physics Neuroinflammation UCL Institute of Neurology, United Kingdom
Academic Background
1998 PhD Doctor of Philosophy – Medical Image Processing University of Surrey
1994 DSC Doctor of Science – Magnetic Resonance Imaging Universita degli Studi di Pavia
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