I am interested in understanding the endogenous pathways that bring about the resolution of acute inflammation. Resolution of acute inflammation is no longer considered a passive event where the response simply fizzles out, but an active process whose dysregulation may explain the complex aetiology of many chronic inflammatory diseases. My overall objective, therefore, is to identify pro-resolution factors that help switch inflammation off and to develop drugs based on their mode of action in order to drive ongoing, chronic inflammatory diseases down a pro-resolution pathway. I contend that this represent a novel approach to understanding and treating diseases driven by ongoing inflammation.