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Dr Daniel Pearce
Room 325 Darwin Building
Gower Street
London
WC1E 6BT
Appointment
  • Lecturer
  • Genetics, Evolution & Environment
  • Div of Biosciences
  • Faculty of Life Sciences
Research Summary

Stem cells have been found in most tissues/organs. These stem cells produce replacements for lost and damaged cells, and it is not completely understood how this regenerative capacity becomes diminished during ageing. One hypothesis is that stem cells are more likely to sacrifice themselves than risk potentially cancer-causing damage being passed onto progeny. This should reduce the incidence of cancer, but ultimately, may lead to a reduction in stem cells with age that contributes to the ageing process.

Current research aims include;

  • Characterisation of age-based alterations in the phenotype and function of murine and human haematopoietic stem cells,
  • Analysis of the role of haematopoietic stem cell-specific antitoxicity mechanisms during ageing
  • Long-term tracking of the dynamics of age-based alterations in stem and progenitor cells
  • Analysis of stem cell epigenetic alterations during ageing and how this alters gene expression
  • Analysis of the effect of calorific restriction on murine haematopoietic stem ageing.


Teaching Summary

BIOL1004: First year key skills

BIOL2004/G004: Fundamentals of Molecular Biology

BIOL3017/3017A/G017/M017: Biology of Ageing

BIOL3024/M024/G024: Advanced Molecular Biology: Genomics and Evolution

Biological Sciences MSci Extended Projects BIOLM030

Biological Sciences MSci Projects BIOLM005 

Biological Sciences Projects BIOL3005 

Biological Sciences Projects BIOL3004 

BIOSG001 (BENGG032): The Scientific Literature

BIOSG002: Biosciences Research Skills

CELL2008 Integrative Cell Biology (Part 1)

Academic Background
2001 PhD Doctor of Philosophy – Cell Biology Kingston University
1997 BSc Bachelor of Science – Biomedical Sciences Kingston University
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