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Dr David Werring
Box 6
UCL Institute of Neurology
London
WC1N 3BG
Appointment
  • Reader in Clinical Neurology
  • Brain Repair & Rehabilitation
  • Institute of Neurology
  • Faculty of Brain Sciences
Research Groups
Research Themes
Research Summary
My research is in stroke, with a range of studies driven by important clinical questions and ecompassing aspects of acute stroke, prevention and rehabilitation. My major interest is in neuroimaging, particularly focussing on the clinical and pathophysiological implications of ischaemic small vessel disease and microbleeds. Microbleeds are small, dot-like areas seen well only on T2*-weighted Gradient Recalled Echo (GRE) images. They are common in patients with ischaemic stroke and intracerebral haemorrhage as well as in healthy older patients. Microbleeds are found adjacent to pathologically abnormal small vessels affected by hypertensive arteriopathy or amyloid angiopathy. Their clinical significance is not yet established, but there is increasing interest in microbleeds as a marker for future bleeding risk, particularly in the large number of stroke patients treated with antithrombotic agents. We are running a portfolio of clinical studies entitled CROMIS (Clinical Relevance of Microbleeds in Stroke). The studies include a propsective observational study of microbleeds in patients treated with antithrombotic drugs, seeking preliminary data as to whether they are associated with an increased future risk of stroke, including intracerebral haemorrhage. Although microbleeds have been generally regarded as asymptomatic, we have previously shown that they are associated with cognitive dysfunction (especially on frontal-executive tasks). We are investigating this association further in longitudinal and case-control studies. Microbleeds may also have diagnostic value in distinguishing between hypertensive arteriopathy and amyloid angiopathy in life, and we are undertaking studies of their anatomical distribution to investigate this.

In the field of acute stroke I am collaborating with UCL Medicine in developing clinical neuroprotection studies in acute stroke using imaging and neurochemical biomarkers of tissue damage.

Finally, I am undertaking clinical research into outcomes and mechanisms in stroke patients with focal spasticity treated with botulinum toxin.
Academic Background
2000 PhD Doctor of Philosophy – Neurology University College London
1992 MBBS Bachelor of Medicine/Bachelor of Surgery – Medicine University of London
1989 BSc Bachelor of Science – Neuroscience University of London
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