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Dr Emmanuel Boucrot
Room 102
Department of Structural and Molecular Biology
Darwin Building , Gower Street
London
WC1E 6BT
Tel: +44 (0)20 7679 4302
Appointment
  • Senior Research Fellow
  • Structural & Molecular Biology
  • Div of Biosciences
  • Faculty of Life Sciences
Biography

2014               Lister Institute Research Prize 

2011 - 2016    BBSRC David Phillips Research Fellow and Principal Investigator, University College London, London (UK)

2008 - 2011    MRC Postdoctoral Fellow, MRC Laboratory of Molecular Biology, Cambridge (UK)
2006 - 2008    HFSP Postdoctoral Fellow, Harvard Medical School, Boston (US) 

2005 - 2006    EMBO Postdoctoral Fellow, Harvard Medical School, Boston (US) 
2001 - 2005    PhD in Immunology (summa cum laude), University of Aix-Marseille II, Marseille (France) 
2000 - 2001    MRes in Immunology, University of Aix-Marseille II, Marseille (France)
1998 - 2000    MSc in Biochemistry, University of Geneva (Switzerland)
1996 - 1998    BSc in Biochemistry, University of Geneva (Switzerland)


Publications: 23 research papers (10 as first author; 4 as corresponding author), 1 review article;  

h-index 20;  over 3,000 citations 


Selected research papers: 

- Renard HF et al. (2014) 'Additive scission functions of endophilin-A2, dynamin and actin in clathrin-independent endocytosis' Nature in press


Boucrot E$ et al. (2014) 'Endophilin marks and controls a clathrin-independent endocytic pathway' Nature in press


- Boucrot E* et al.  (2012) 'Membrane fission is promoted by insertion of amphipathic helices and is restricted by crescent BAR domains' Cell 149 (1) pp.124-36


- Henne WM*, Boucrot E*,$ et al. (2010) 'FCHo proteins are nucleator of clathrin-mediated endocytosis'  Science 328 (5983) pp.1281-4   


- Boucrot E et al. (2005) 'The intracellular fate of Salmonella depends on the recruitment of kinesin'  Science 308 (5725) pp.1174-8


review article:
- McMahon HT$ and Boucrot E$ (2011) 'Molecular mechanisms and physiological functions of clathrin-mediated endocytosis'                       Nat Rev Mol Cell Biol  12 (8) pp.517-33

 

* joint first authors    $ corresponding author

Click here for full list of publications

Research Summary

Understanding molecular mechanisms and establishing functions of intracellular membrane trafficking in health and disease.

Work in my group focuses on dissecting molecular mechanisms of intracellular membrane trafficking during cell regeneration, cell migration and bacterial infection and understanding their perturbations during some diseases.


Project 1: Regulation of membrane trafficking by reversible phoshorylation during cell division

Improper cellular regeneration compromises healing, accelerates ageing and is involved in cancer development. Cell replacement is achieved by cell division. Reversible phosphorylation controls many cellular processes, including cell division and membrane trafficking. We are combining global phospho-proteomics, high-throughput screening microscopy with classical biochemistry and cell biology assays to dissect the mechanisms of phospho-regulation of membrane trafficking during cell division. These studies are expected to contribute to our global understanding of the regulation of cellular membrane exchanges, cell division and regeneration.



Project 2: Mechanisms of clathrin-independent endocytosis

Endocytosis is the process by which cells acquire substances from the extracellular space and  internalise transmembrane cell surface proteins, of which receptors are a major class. The process occurs through invaginations of the plasma membrane forming endocytic vesicles that, once pinched off the surface, are transported to endosomes and, from there, sorted to the appropriated cellular destinations depending on the fate of the receptor. We recently discovered a new pathway of endocytosis, the Fast Endophilin-Mediated Endocytosis (FEME) pathway (Boucrot et al. 2014 Nature; Renard et al. 2014 Nature). Our goal is to establish the functions and molecular mechanisms of this novel route of entry into cells.


This project is funded by a 2014 Lister Institute Research Prize 


Current group members:

Dr Ana Mendes-Pereira (PDRA funded by BBSRC) 

Dr Kieran McGourty (PDRA funded by BBSRC)

Mr Antonio Ferreira (PhD student funded by FCT)

Ms Claudia Hinze (PhD student funded by the British Heart Foundation)

Ms Ilaria Di Meglio (UCL MRes student)

Ms Leonor Quintaneiro (visiting student)


Collaborations

External: Prof. Jonathon Pines (Gurdon Institute, Cambridge), Dr Ludger Johannes (Curie Institute, Paris), Dr Nathalie Sauvonnet (Pasteur Institute, Paris,), Dr Madan Babu (MRC LMB, Cambridge)

UCL: Prof. Linda Partridge (GEE), Prof. David Samson (Dept of Medicine), Dr Konstantinos Thalassinos (SMB), Dr Richard Hayward (SMB), Prof. Kaila Srai (SMB)

Teaching Summary

BIOC1007 and BIOC2001 - Tutor

BIOC3002, BIOC3027 and BIOC3004 - Supervisor, first and second marker
BCBC006S6 (Birkbeck) Advanced Cell Biology - Lecturer and joint course organiser
UCL PhD in Molecular Cell Biology - Tutor
UCL MSc and MRes - Supervisor

Academic Background
2005 PhD Doctor of Philosophy – Immunology Universite de la Mediterranée (Aix Marseille II)
2001 MRes Master of Research – Immunology Universite de la Mediterranée (Aix Marseille II)
2000 MSc Master of Science – Biochemistry Universite de Genève
1998 BSc Bachelor of Science – Biochemistry Universite de Genève
Please report any queries concerning the data shown on this page to https://www.ucl.ac.uk/hr/helpdesk/helpdesk_web_form.php
University College London - Gower Street - London - WC1E 6BT Tel:+44 (0)20 7679 2000

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