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Dr Liz Jury
4th Floor Room 415
Rayne Building
5 University Street
London
WC1E 6JF
Tel: 020 3108 2154
Appointment
  • Principle Research Associate
  • Inflammation
  • Div of Medicine
  • Faculty of Medical Sciences
 
 
Biography

Dr Jury started her career at St Bartholomew’s Hospital, London developing the Immunopathogology service specialising in the diagnosis of autoimmunity, immunodeficiency and immunophenotyping. She moved to a more research focused career joining Prof David Isenberg’s team in 2000 and now leads her own research group within the Centre for Rheumatology Research at University College London. Dr Jury’s work has developed new areas of research into signalling abnormalities in T and B cells from patients with systemic lupus erythematosus (SLE) making a significant contribution towards understanding the nature of these abnormalities and how they relate to disease pathogenesis

Research Summary

The main focus of Dr Jury's research is to understand the role of plasma membrane, cellular and serum lipids on immune cell activation. Dr Jury was one of the first to identify defects in plasma membrane lipids in T cells from patients with SLE (1,2). She revealed that these defects contributed to T cell hyperactivirty and has shown that by manipulating cholesterol biosynthesis using atorvastatin some of the signalling and functional defects seen in T cells from patients can be reversed (3). More recently Dr Jury has used a new approach to visulaise the organisation (order) of plasma membrane lipids and found that T cells have specific patterns of membrane order that correlate with their function (4). Importantly, she has shown that manipulation of membrane order can control T cell function, adding weight to her hypothesis that therapeutic targeting of membrane lipids can correct aberrant immune cell activation. Dr Jury has also shown that invariant Natural Killer T cells (iNKT), a unique subset of T cells that recognise lipid antigen, are deficient in SLEpatients. Intersetingly iNKT cell defects were reversed in patients responding to rituximab therapy(5).

Research projects include:


a)  iNKT cells in autoimmunity and atherosclerosis in patients with SLE.

b) Investigating serum and membrane lipid interaction.

c) The importance of lipid biosynthesis pathways in immune cell function.

d) Investigating the metabolic and immunological features contributing to immunogenicity in patients treated with biological therapies.

Teaching Summary

·         Supervision of PhD students

·         Supervision of MSc and BSc student laboratory projects.

·         Lecture for Intercalated BSc Immunology and Clinical Immunology of Bone and Joint Disease courses.

·         Personal tutor for Department of Medicine-organised MSc courses and MBBS Programme.

 

Academic Background
2004 PhD Doctor of Philosophy University of London
1998 MSc Master of Science University of London
1984 IBMSSE IBMS Special Examination Institute of Biomedical Scientists
1982 HNC Higher National Certificate Paddington College
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