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Dr Emma Morris
Department of Immunolgy, UCL Medical School
Royal Free Campus, Royal Free Hospital
London
NW3 2PF
Tel: +44 (0) 20 7794 0500 ext 33741
Fax: +44 (0) 20 7433 1943
Appointment
  • Reader in Immunology and Immunotherapy
  • Research Department of Immunology
  • Div of Infection & Immunity
  • Faculty of Medical Sciences
Research Summary
* Novel approaches for generation of antigen-specific T cells for leukaemia and cancer immunotherapy. * Retroviral gene transfer of T cell receptor (TCR) genes into T cells and haematopoietic stem cells to re-direct antigen-specificity. * The generation of MHC class I-restricted tumour antigen-specific CD4+ helper T cells to augment CD8+ T cell mediated tumour immunotherapy. * Analysis of functional avidity and signalling pathways of tumour antigen-specific TCRs. * Investigation of the role of the CD8 co-receptor in TCR transduced CD4+ helper T cells and conventional CD8+ T cells. * The generation of pre-clinical models for the evaluation of WT1-specific immunotherapy (WT1 is a tumour associated antigen over-expressed in myelodysplasia (MDS), leukaemias (AML, CML), breast, ovarian, prostate and colon cancers. * Isolation of TCRs from T cell clones specific for tumour antigens. * Generation of antigen-specific regulatory T cells using TCR gene transfer.
Teaching Summary
Member of Panel of Examiners for Haematology FRCPath, Royal College of Pathologists, UK. Educational supervisor to two CMT doctors (Acute Medicine, UCLH). Bone Marrow Transplant and Immunology/Immunotherapy lecturer for North Thames London Haematology SPR Rotation Trainees. Regular teaching (lectures) of UCL BSc and MSc students and Medical Students (UCL Medical School). UCL iBSc and MSc student supervision for lab-based research projects (2 students/year). Regular teaching of Junior Doctors (UCLH) in Bone Marrow Transplant Clinics at UCLH NHS Trust. Educational Supervisor for Haematology Specialist Registrars training on the UCLH/RFH Haematology SpR Rotation. UCLH Haematology SpR Rotation Mentor
Appointments
  Joint Director of R&D, Royal Free Hospital    , United Kingdom
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