UCL  IRIS
Institutional Research Information Service
UCL Logo
Please report any queries concerning the funding data grouped in the sections named "Externally Awarded" or "Internally Disbursed" (shown on the profile page) to your Research Finance Administrator. Your can find your Research Finance Administrator at https://www.ucl.ac.uk/finance/research/rs-contacts.php by entering your department
Please report any queries concerning the student data shown on the profile page to:

Email: portico-services@ucl.ac.uk

Help Desk: http://www.ucl.ac.uk/ras/portico/helpdesk
 More search options
Dr Elisabeth Nacheva
UCL Med School, Royal Free Campus
Dept of Academic Haematology, Rowland Hill Street
London
NW3 2PF
Tel: 020 7472 6176
Fax: 020 73177534
Appointment
  • Honorary Reader
  • Cancer Institute
  • Faculty of Medical Sciences
Research Groups
Research Themes
Research Summary




My research is devoted to understanding the role of genetic changes in cancer using as a model malignant hematological disorders. By searching for recurrent chromosome and gene abnormalities we aim to get insights into the events that lead to disease initiation and progression. These insights not only clarify the biology but also empower the diagnosis and treatment of these diseases.  My team pioneered the use of fluorescence in situ hybridization (FISH) for identification, quantification and chromosome localisation of gene rearrangements in leukemia thus contributing to the formulation of molecular cytogenetic techniques as an essential part of the diagnosis and management of leukemia. Current work includes several topics in Philadelphia positive disease including genomic array investigations of the evolution of blast crisis in CML, genome profile of acute and chronic BCR/ABL1 positive disease, genome aberrations associated with donor cell leukemia, factors influencing the development of resistance to tyrosine kinase inhibitors and the genomic profile of CD34(+) progenitor cells. 











Please report any queries concerning the data shown on this page to https://www.ucl.ac.uk/hr/helpdesk/helpdesk_web_form.php
University College London - Gower Street - London - WC1E 6BT Tel:+44 (0)20 7679 2000

© UCL 1999–2011

Search by