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Dr Filipe Gomes Cabreiro
610A
Darwin Building
Institute of Structural and Molecular Biology
London
WC1E 6BT
Appointment
  • Sir Henry Dale Fellow
  • Structural & Molecular Biology
  • Div of Biosciences
  • Faculty of Life Sciences
Biography
Filipe Cabreiro obtained his undergraduate degree in Applied Biochemistry from the University of Porto, Portugal. Following the success of his undergraduate studies, he qualified for a research fellowship from the French government. During Filipe’s Masters and PhD in Biochemistry at the Université Paris Diderot in France, he exploited the biological mechanisms underlying molecular stress protection and zinc homeostasis (Cabreiro et al., JBC 2008; Cabreiro et al., Antiox redox signal. 2009). In 2008, Filipe joined the group of Dr David Gems within the Institute of Healthy Ageing (IHA)/GEE at UCL as a post-doctoral researcher. Since this time, Filipe has broadened his background knowledge in several key areas such as genetics, molecular biology, metabolism and microbiology. Indeed, he undertook several projects simultaneously to investigate different aspects of ageing. These topics included the role of antioxidant metabolism and signaling in ageing (Cabreiro et al., Free Radic. Biol. Med. 2011), the role of sirtuins in ageing and disease (Cabreiro et al., Nature 2011), and the role of the anti-diabetic drug metformin in C. elegans metabolism and ageing (Cabreiro et al., Cell 2013). This final work has led onto developing a focus on host-microbiota interactions and metabolic disorders. Filipe has become an expert in a new model organism system, C. elegans and is pioneering the study of drug-microbiota interactions using this model (Cabreiro and Gems, EMBO Molec. Med. 2013). He is currently a Sir Henry Dale Fellow at the Institute of Structural and Molecular Biology at UCL after being awarded a fellowship from the Royal Society/Wellcome Trust to explore the gut microbial action of metformin and develop strategies to target the microbiota to treat metabolic disease.

In terms of public engagement, Filipe was involved in the “Healthy Ageing” stand organised by the IHA, UCL for the Summer Science 2012 festival at the Royal Society, and at Bangkok Science and Technology Fair 2012, which is open to schools and the general public to inform people on how diet affects ageing and how can we study these effects using simple and tractable model organisms. More recently, he has participated and interviewed for a podcast for Radio Cardiff's science show, Pythagoras Trousers on the role of the microbiome in health.

Appointments
01-FEB-2014 – 31-JAN-2019 Sir Henry Dale Fellow    , United Kingdom
Academic Background
2008 PhD Doctor of Philosophy – Biology and Biochemistry Universite Denis Diderot (Paris VII)
2004 MAST Master – Biochemistry Universite Denis Diderot (Paris VII)
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