Help Desk: http://www.ucl.ac.uk/ras/portico/helpdesk
- Reader in Human Neurophysiology
- Neuro, Physiology & Pharmacology
- Div of Biosciences
- Faculty of Life Sciences
My research group (click here for more details) studies the neurophysiology of sensory systems in humans, with particular interest on the nociceptive system.
Our approach is to combine psychophysics and laboratory techniques (like electromyography [EMG], electroencephalography/magnetoencephalography [EEG/MEG] and functional magnetic resonance imaging [fMRI], often performed simultaneously) to provide a readout of the function of the central nervous system at different levels, in response to external stimuli belonging to various sensory modalities (e.g. auditory, visual, somatosensory). To explore the function of the nociceptive system we use these functional neuroimaging tools during cutaneous laser stimulation - a technique that I have been using and developing since 1999 and that allows selective activation of A-delta and C nociceptive terminals.
The functional imaging responses elicited by nociceptive stimuli are recorded widely. However, their usefulness in unravelling the neural mechanism of pain perception is limited, as they consist in a mixture of neural activities encoding specific features of the peripheral nociceptive input (like quality, intensity and location of the stimulus), as well as non-specific neural activities (encoding, for example, stimulus novelty and saliency).
Therefore, our research is currently focusing on developing and applying advanced analytical approaches to better understand what we really ‘see’ from the obtained brain waves or brain images. More precisely, we are currently interested in understanding the physiological and psychological processes underlying:
(1) The transmission and modulation of ascending nociceptive signals
(2) The generation of painful percepts following nociceptive stimulation
(3) The detection and reaction to salient events occurring in the sensory environment
(4) The modulation of pain perception and withdrawal reflexes by body posture
From a more technical point of view, we are interested in:
(5) Developing novel statistical approaches to analyse EEG and fMRI responses
(6) Analysing EEG and fMRI data collected simultaneously
I am the joint-director of the MRes Programme at CoMPLEX (www.ucl.ac.uk/complex)
|01-OCT-2009||Royal Society University Research Fellow||Neuroscience Physiology and Pharmacology||University College London, United Kingdom|
|01-MAR-2008 – 30-SEP-2009||University Research Lecturer||Physiology, Anatomy and Genetics||University of Oxford, United Kingdom|
|01-OCT-2006 – 30-SEP-2009||Royal Society University Research Fellow||Physiology, Anatomy and Genetics||University of Oxford, United Kingdom|
|01-OCT-2006||Fellow by Special Election||St Catherine's College||University of Oxford, United Kingdom|
|2003||PhD||Doctor of Philosophy||Universita degli Studi di Roma La Sapienza|
|1999||MD||Doctor of Medicine||Universita degli Studi di Roma La Sapienza|