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Prof Ian Zachary
University College London, Rayne Building
5 University Street
London
WC1E 6JJ
Tel: 020 7679 6620
Fax: 020 7679 6212
Appointment
  • Professor of Vascular Cell Biology
  • Metabolism & Experimental Therapeutics
  • Div of Medicine
  • Faculty of Medical Sciences
 
 
Research Themes
Research Summary
The overall goals of research in my laboratory are to understand the molecular mechanisms through which VEGF and other growth factors and their receptors regulate the function of endothelial cells, angiogenesis (formation of new blood vessels), and the adult cardiovascular system; and, where possible, to translate these findings into new therapeutic approaches to human disease. Major focuses of our research are identification of novel signalling mechanisms and gene regulation events important for mediating biological functions of VEGF, and the role of the VEGF co-receptor Neuropilin. We are addressing these problems using a diverse palette of techniques in cell, molecular and in vivo biology, including the functional analysis of mutant receptors, overexpression and knockdown of functional signalling molecules, mammalian models of cardiovascular disease, the generation of novel genetically altered mice (knock-in/knock-out), and Zebra fish.
Teaching Summary
I lecture and give tutorials on angiogenesis in the Heart and Circulation Course at UCL, and will teach a module in the new MSc in Clinical and Experimental Medicine. Supervision of PhD students, and laboratory-based projects for BSc and MSc students
Academic Background
1987 PhD Doctor of Philosophy Imperial Cancer Research Fund
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