My research interests are centred upon the study of the pathogenesis of theautoimmune rheumatic diseases; principally Systemic Lupus Erythematosus (SLE)and the Antiphospholipid syndrome (APS). In particular, I am interested in cellular mechanisms underlying vascular thrombosis and atherosclerosis andwhether these processes are distinct from those that give rise to pregnancymorbidity in these patients. The three main areas of my current researchprogramme are: - identifying the molecular properties of pathogenic autoantibodiesin patients with the APS and SLE; developing diagnostic assays and novel therapies to improvemanagement of patients with APS; andinvestigating the mechanisms of pregnancy morbidity in patients with autoimmune rheumaticdisease.