Help Desk: http://www.ucl.ac.uk/ras/portico/helpdesk
- Professor of Cancer Biochemistry
- Structural & Molecular Biology
- Div of Biosciences
- Faculty of Life Sciences
The main focus of research in my laboratory is the study of basic mechanisms by which cell growth and metabolism are regulated in normal and cancer cells. There are two major areas of interest in the laboratory: a) regulation of cellular functions via the mTOR/S6K signalling pathway; and b) the role of Coenzyme A and its derivatives in cellular metabolism and gene expression. The development of novel diagnostic and therapeutic approaches for cancer is the ultimate goal of our research, which we pursue through collaboration with academic and industrial partners. We have an ongoing collaboration with Johnson & Johnson on targeting ribosomal S6 kinases for the development of novel anti-cancer drugs. In addition, we collaborate with Xanofi Ltd on utilizing nanofibre/microfibre scaffolds developed by this biotech company for 3D cell culturing and setting up 3D cancer models for academic research and testing the efficacy of new cancer drugs. Our challenge is to establish highly reproducible in vitro cultivation of patient-derived cancer and stromal cells, both from primary samples and associated lymph node and distant metastases in optimized nano/microfiber scaffolds in order to evaluate anti-cancer drug sensitivity for personalized anticancer chemotherapy.
I am the Graduate Admission Tutor in the Department of Structural and Molecular Biology, the Lead Tutor in Biotechnology for the MRes in Biosciences and course organizer BIOC2014. I lecture and give tutorials on growth regulation and cell signalling to second and third year students. I also supervise third year students for laboratory projects. I am course organiser for CPD Lecture and Practical course “Lab Techniques in Mammalian Cell Biology” at UCL.
|2003||Professor of Cancer Biochemistry||Biosciences||University College London, United Kingdom|
|1996 – 2003||Group Leader||Growth Regulation||Ludwig Institute for Cancer Research, UCL Branch, United Kingdom|
|1993 – 1996||Senior Research Scientist||Cell Signalling||Ludwig Institute for Cancer Research, UCL Branch, United Kingdom|
|1989 – 1993||Postdoctoral Fellow||Cell Signalling||Ludwig Institute for Cancer Research, United Kingdom|
|1988 – 1989||IARC Postdoctoral Fellow||Cell signalling||Ludwig Institute for Cancer Research, United Kingdom|
|1987||PhD||Doctor of Philosophy – Biochemistry||National Academy of Science|
|1983||MD||Doctor of Medicine – Medicine||Lviv Medical University|