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Dr Joyce Harper
UCL Centre for PGD, IWH
UCL, 86-96 Chenies Mews
London
WC1E 6HX
Appointment
  • Reader in Human Genetics and Embryology
  • Reproductive Medicine
  • Inst for Women's Health
  • Faculty of Population Health Sciences
 
 
Research Summary
Principal investigator of UCL Centre for PG & D and person responsible for the HFEA Research Licence and head of research and development at the Assisted Conception Unit, UCLH. UCL Centre for PG & D covers a range of research interests in preimplantation genetics, ranging from DNA damage and aneuploidy in sperm to methylation patterns in human embryos. At the London Fertility Centre I was working on ways to help identify the best embryo for transfer. When I initially started work on PGD (Wellcome grant) I used FISH to examine chromosome arrangements in human embryos and was the first to report the high levels of mosaicism that have now been observed by many other groups internationally. I have also been trying to elucidate the mechanism of these abnormalities, which includes abnormalities in cell cycle checkpoints. This work has been sponsored by an MRC JREI Equipment Grant, Tommy's Campaign and UCL Special Trustees. Our Wellbeing grant was used to apply these techniques to study human oocytes. I am principal investigator of UCL Centre for PG & D and person responsible for the HFEA Research Licence. I am head of research and development at the Assisted Conception Unit, UCLH. See publication list (link to this page). Main topics: * Mechanism of mosaicism in preimplantation embryos * Whole genome amplification and microarray methods to use on single human embryonic cells * DNA fragmentation and aneuploidy in sperm * Methylation patterns of preimplantation embryos * Metabolomics of the human embryo and relation to aneuploidy * All aspects of infertility related research
Teaching Summary
I lead the above two MSc and PG Diploma courses. For full details see the MSc web site - www.ucl.ac.uk/~rmjbjoh/msc.htm
Academic Background
1988 PhD Doctor of Philosophy King's College London
1984 BSc Bachelor of Science University of London
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