UCL  IRIS
Institutional Research Information Service
UCL Logo
Please report any queries concerning the funding data grouped in the sections named "Externally Awarded" or "Internally Disbursed" (shown on the profile page) to your Research Finance Administrator. Your can find your Research Finance Administrator at http://www.ucl.ac.uk/finance/research/post_award/post_award_contacts.php by entering your department
Please report any queries concerning the student data shown on the profile page to:

Email: portico-services@ucl.ac.uk

Help Desk: http://www.ucl.ac.uk/ras/portico/helpdesk
 More search options
Prof Helen Cross
Neurosciences Unit, The Wolfson Centre
Mecklenburgh Square, UCL
London
WC1N 2AP
Appointment
  • The Prince of Wales's Chair of Childhood Epilepsy & Head of UCL-ICH Neurosciences Unit
  • ICH Developmental Neurosciences Prog
  • Institute of Child Health
  • Faculty of Pop Health Sciences
Biography

Professor Helen Cross is the Prince of Wales’s Chair of Childhood Epilepsy at UCL-Institute of Child Health, Great Ormond Street Hospital for Children, London and the National Centre for Young People with Epilepsy, Lingfield, UK. She has research interests in early onset complex epilepsy, particularly outcomes and the role of intervention, particularly surgery and the ketogenic diet, publishing more than 115 peer reviewed primary research articles and 50 review articles. She has also edited of four books, including a definitive childhood epilepsy text and a ketogenic diet cookery book, as well as written more than 40 chapters. She was Chair of the ILAE Commission for Paediatrics 2005-2009,  Co-Chair of the Task Force of the Global Campaign and a member of the ILAE Commission for European Affairs, in which she chaired the subcommission for education 2009-2013. She was Chair of the ILAE Task Force for Paediatric Epilepsy Surgery 2001-2013. She was Clinical Advisor to the 2012 review of the NICE guidelines for the Diagnosis and Management of the Epilepsies in adults and children  as well as Chair of the Trustees of Epilepsy Research UK 2005-2011. She is currently elected Secretary General of the ILAE 2013-2017, Clinical Advisor to the national Childrens Epilepsy Surgery Service and Chair of the Steering Committee for the BPNA Paediatric Epilepsy Training Courses.

Research Summary

 Imaging in children with focal epilepsy the development of a noninvasive approach to presurgical evaluation My initial research was into the development of noninvasive functional and optimised structural imaging in the presurgical assessment of children with drug resistant focal epilepsy. This work evaluated the use of optimised magnetic resonance imaging, including quantitative techniques of T2 relaxometry and proton magnetic resonance spectroscopy , as well as ictal and interictal single photon emission computed tomography (SPECT). Ictal and interictal SPECT now form part of the routine clinical presurgical evaluation at Great Ormond Street Hospital for Children NHS Trust.  Ongoing work includes evaluation of newer MRI techniques in determining structural abnormality, as well as combining functional and structural techniues wirh EEG fMRI
Why do children with early catastrophic epilepsy have a high rate of cognitive and behavioural comorbidity, what are the mechanisms of such and can we alter the natural history with early surgical intervention? With the development of the epilepsy surgery programme at Great Ormond Street Hospital, it has been our responsibility to evaluate benefits as well as prognostic indicators from such procedures. However, it has also given us the opportunity to evaluate the underlying cognitive and psychiatric morbidity associated with such epilepsy including the natural history. This has been in conjunction with neuropsychiatry as well as ongoing projects with neuropsychology. It is anticipated that in addition to the studies in progress, further follow up neuropsychology and MRI correlative studies, may also contribute to some understanding of this. A prospective epidemiological study of focal epilepsy with onset in infancy (grants awarded by Epilepsy Research Foundation, Bailey Thomas Charitable Trust The Foyle Foundation), has highlighted the high rate of neurodevelopmental disorder at presentation with epilepsy. Further work continues to determine the relative role of pathology and epileptic discharges in cognitive dysfunction
What is the role of other intervention can we determine a role for alternative treatments and the timing of such compared to that presently available? Current anticonvulsant medications in the majority have been found anecdotally to be effective, and in addition many are trialled late in children, in ways not specifically related to clinical practice. I have been involved in international collaborative drug trials. I have also been instrumental as the principal investigator in conducting the first randomised controlled trial of the ketogenic diet in the treatment of childhood epilepsy, recently published. Pathological, neurophysiological and genetic studies (from our own unit and others) have suggested alternative modes of epileptogenesis to our current understanding and reasons why individuals are resistant to existing medication, implying other possible treatments may be effective. Collaboration with colleagues in the Epilepsy Unit at the Institute of Neurology, Queen Square has enabled involvement in pathological and genetic studies

Teaching Summary

Professor Cross has been extensively involved in teaching with regard to epilepsy at a postgraduate level both nationally and internationally. She was integral to the development of the standardised Paediatric Epilepsy Training (PET) Courses by the British Paediatric Neurology Association, currently Chair of the PET Steering Committee. She also teaches extensively on internal MSc (neuropsychology, genetics, advanced imaging, child mental health) as well as external (Kings, MSc in epilepsy). She has been on faculty and organising committees  of several internationally run courses  including San Servolo Summer Schools, Eilat Educational Pharmacology Course and EPODES (epilepsy surgery). She is regularly asked to speak at international congresses and teaching courses.

Appointments
01-JUN-2008 The Prince of Wales's Chair of Childhood Epilepsy Neuroscience UCL-Institute of Child Health, United Kingdom
01-OCT-2007 – 31-MAY-2008 Professor Neuroscience UCL-Institute of Child Health, United Kingdom
01-OCT-2004 – 30-SEP-2007 Reader Neuroscience UCL-Institute of Child Health, United Kingdom
01-DEC-2002 – 30-SEP-2004 Senior Lecturer Neuroscience UCL-Institute of Child Health, United Kingdom
01-APR-1996 – 30-NOV-2002 Consultant Neurology Great Ormond Street Hospital for Children, United Kingdom
Please report any queries concerning the data shown on this page to https://www.ucl.ac.uk/hr/helpdesk/helpdesk_web_form.php
University College London - Gower Street - London - WC1E 6BT Tel:+44 (0)20 7679 2000

© UCL 1999–2011

Search by