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- Professor of Synthetic Biology for Bioprocessing
- Dept of Biochemical Engineering
- Faculty of Engineering Science
I studied Biochemistry at the University of Bristol and graduated in 1975. I moved departments and joined the Department of Bacteriology to carry out research for my PhD on antibiotic resistance plasmids and transposable elements using the newly discovered restriction enzymes. After gaining my doctorate in 1981 I moved to UMIST in Manchester to a postdoctoral position on Pseudomonas catabolic plasmids. In 1983 I came to University College and started the MSc in Applied Molecular Biology and Biotechnology. I ran the MSc course for 17 years and in 2001 took over as programme tutor for the BSc in Biotechnology. I was appointed Professor of Molecular Microbiology in 2006.
- Bioconversion Chemsitry Engineering Interface Programme (BiCE)
- Cellular Microbiology
- CoMPLEX Research Group
- Innovative Manufacturing Research Centre in Bioprocessing
- Institute of Biomedical Engineering (IBME) Consortium
- Institute of Structural & Molecular Biology, UCL/Birkbeck
- UCL Computational Life and Medical Sciences Network
- UCL Innovative Manufacturing Research Centre in Bioprocessing
- UCL Systems Biology
My research interests are in the use of bacteria, enzymes and phages to develop new chemicals, pathways and active entities. See: http://www.smb.ucl.ac.uk/synbion/
On joining UCL I started a productive collaboration with the Department of Biochemical Engineering at UCL and with them have investigated several enzyme systems (dioxygenases, transketolase, Baeyer-Villiger mono-oxygenases, cytochrome P450's and transaminases) with the aim of producing robust biocatalysts. In addition, with colleagues in the Department of Chemistry we are developing the de novo construction of biosynthetic pathways for chiral molecules. I am a member of the IMRC in Biochemical Engineering and use cell engineering to aid the bioprocessing of plasmid DNA, recombinant proteins and phages. I am a founding PI in the BiCE group and this Biocatalysis Team has won two awards in 2010. With colleagues at the Eastman Dental Institute we are investigating the interaction of commensal and pathogenic bacteria with the human host using metagenomics and phage display to isolate adhesins. The techniques of metagenomics and my interest in novel bacteria have led to collaborations in the area of astrobiology. I use the techniques and concepts of Synthetic Biology in the construction of novel pathways for making chiral molecules and the use of phages in electronic and optical applications.
I am degree programme tutor of the MRes in Synthetic Biology.
I teach on the first year BIOC1007 course, the second year courses BIOC2001, BIOC2005, BIOC2014 and the final year courses BIOC3004 and BIOC3005.
I also teach on the new MRes in Synthetic Biology which I founded in 2010.
|1981||PhD||Doctor of Philosophy||University of Bristol|
|1976||BSc Hons||Bachelor of Science (Honours)||University of Bristol|