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- Structural & Molecular Biology
- Div of Biosciences
- Faculty of Life Sciences
I received my scientific training at The University of Copenhagen, Denmark and at the National Institute for Medical Research, UK, where I continued working with M. tuberculosis until I moved to UCL in spring 2013.
Mycobacterium tuberculosis, remains a major threat to global health. It is responsible for more deaths than any other bacterium and claims around 1.5 million lives every year in a deadly synergy with HIV, leaving ten million children orphaned by this disease. Rational design of drugs and vaccines to combat tuberculosis is currently hampered by limitations in basic understanding of the biology of the bacterium. M. tuberculosis persists in the human host as multiple subpopulations, an adaptation that requires significant and appropriate changes in gene expression. The regulation of gene expression in M. tuberculosis has until recently been dominated by a protein-centric view. However, there is currently no doubt that regulatory RNA, including small RNAs play a crucial role in the adaptation of bacterial pathogens to the host environment. Our research aims at identifying and characterising small RNAs in M. tuberculosis. By manipulating the levels of small RNAs we will be able to detect which genes may be affected by the small RNAs, what molecular mechanisms are involved and the impact this has on M. tuberculosis pathogenesis.
I am teaching at the BIOC3003 and BIOC3024 courses
|01-APR-2013||Lecturer||Structural Molecular Biology||UCL, United Kingdom|