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Dr Laurent Bozec
459
Faculty of Dentistry - University of Toronto
124 Edward Street
Toronto
Canada
M5G 1G6
Appointment
  • Honorary Senior Lecturer
  • Eastman Dental Institute
  • Faculty of Medical Sciences
Biography

Laurent Bozec was the Head of Research and Director of the Eastman Centre for Postgraduate Research  at the Eastman Dental Institute, University College London from 2015 until 2018. He then he joined the Faculty of Dentistry at the University of Toronto, Canada in November 2018. 

At the Faculty, he is now a Professor (Associate) in Nanometrology and Dental Sciences. He can be contacted directly through the faculty: https://www.dentistry.utoronto.ca/faculty-profiles/laurent-bozec

He remains an Honorary  Senior Lecturer/Associate Professor in Biophysics and Nanometrology at the UCL Eastman Dental Institute. He holds also the same position at King's College Dental Institute.


Research Summary

Investigating the mechano-biology of tissues at the nanoscale is paramount to establish not only the link between their forms and functions but also the inception of several diseases and disorders. With expertise in nanometrology and especially AFM & nanomechanics, Bozec’s group focusses primarily on “Mechano-Biology for Healthcare” in research fields related to ageing, connective and mineralised tissue disorders and finally bacteriology


Current Research topics in Bozec's group:

Over the years, Bozec's group has demonstrated leadership in AFM metrology at UCL focussing on the combination of imaging and mechanical approaches at the nano and mesoscale. Through a large number of collaborations with academic colleagues and industrial partners, we have been able to characterise a wide range of samples, ranging from single protein on surface to recellularised hydrogels and 15th Cent. parchments extracts for example.


1) Living-Probe

In this area of research, we are interested in functionalising AFM probe with "live-cell" in order to investigate the host-cell interactions. Using the AFM, we are routinely now functionalising probes with stem cells, fibroblasts, fungal and bacterial (gram+ and -) cells to measure their response to external stimuli as well as their adhesion with surfaces.  


2) Quantitative Nano-Histology 

In this area of research, we are pushing the boundaries of traditional histological assessment by combining it with other materials characterisation modalities, such as AFM based nanomechanics as part of an adjunct diagnostics setup.

Using our expertise in collagen characterisation, we are able to review tissues affected by rare syndromes such as Ehlers Danlos, Osteogenesis Imperfecta and Scleroderma. As part of this project we are also working on the impact of Advanced Glycation End products on the physical and mechanical properties of collagen tissues (human and model) at the nanoscale. 


3) Evaluation of Optical Coherence Tomography as a diagnostics tool for dentistry and its applications to dental anomalies and other defects.

In this area of research, we are keen to promote the use of OCT as part of clinical diagnostics for specific dental assaults and are developing both basics knowledge and metric to use this as an adjunct diagnostic approach.



Teaching Summary

Recruiting new students:


https://www.findaphd.com/phds/project/clinical-translation-of-quantitative-nano-histology/?p106326

Appointments
01-NOV-2018 Professor (Associate) Faculty of Dentistry University of Toronto, Canada
01-OCT-2018 Honorary Senior Lecturer/Assoc. Professor UCL Eastman Dental Institute University College London, United Kingdom
01-MAR-2018 Honorary Senior Lecturer/Assoc. Professor Dental Institute King's College London, United Kingdom
29-JUL-2015 – 31-JUL-2018 Head of Research Eastman Dental Institute University College London, United Kingdom
01-OCT-2013 – 29-SEP-2018 Senior Lecturer in Biophysics and Nanometrology Biomaterials & Tissue Engineering - Eastman Dental Institute University College London, United Kingdom
01-SEP-2007 – 30-SEP-2013 Lecturer Biomaterials and Tissue Engineering Eastman Dental Institute - University College London, United Kingdom
01-SEP-2005 – 31-AUG-2007 Senior Research Fellow Medicine / London Centre for Nanotechnology University College London, United Kingdom
11-OCT-2002 – 31-AUG-2007 Research Fellow Medicine / London Centre for Nanotechnology University College London, United Kingdom
Academic Background
2002 PhD Doctor of Philosophy – Physics University of Lancaster
1999 BSc Hons Bachelor of Science – Applied Physics Nottingham Trent University
1995 Baccalaureate Baccalaureate – Science  
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