UCL  IRIS
Institutional Research Information Service
UCL Logo
Please report any queries concerning the funding data shown on the profile page to:

http://www.ucl.ac.uk/finance/secure/research/post_award
Please report any queries concerning the student data shown on the profile page to:

Email: portico-services@ucl.ac.uk

Help Desk: http://www.ucl.ac.uk/ras/portico/helpdesk
 More search options
Appointment
  • Lecturer
  • Genetics, Evolution & Environment
  • Div of Biosciences
  • Faculty of Life Sciences
Biography
Lazaros Foukas obtained a PhD in Biochemistry from University College London. He then
went on to conduct postdoctoral research in Bart Vanhaesebroeck’s lab in the
Ludwig Institute for Cancer Research and then in Barts Cancer Institute, Queen
Mary University of London. He joined the Institute of Healthy Ageing at UCL as
a principal investigator in 2009. His research focuses on the role of
signalling pathways in age related pathologies, such as cancer and metabolic disease.
Research Groups
Research Themes
Research Summary

Ageing is a process of gradual decline in the physiological functions of the organism. Amongst other derangements, ageing is associated with dysfunction in carbohydrate and lipid homeostatic regulatory mechanisms. Consequently, middle-aged and old individuals have a higher risk of suffering from metabolic disorders. The rapidly increasing incidence of obesity and type-2 diabetes necessitates the development of novel therapeutic agents to combat these conditions and their numerous debilitating complications.



Cell signalling pathways have been successfully targeted in the therapy of major diseases, such as cancer and inflammation. Signalling pathways that sense nutrient availability and regulate metabolic responses represent potential points of intervention for treatment of metabolic disorders. Key signalling pathways in metabolic regulation are the PI 3-Kinase (PI3K) and Target of Rapamycin (TOR) pathways.



We aim to study the mechanisms by which growth factor and nutrient sensing signalling pathways regulate metabolism and the impact of their perturbation on health in the context of ageing. We use a combination of mammalian genetics, cell based models and pharmacological approaches to identify components of cell signalling pathways which can be targeted in prevention or therapy of age-related diseases.

Academic Background
2003 PhD Doctor of Philosophy University College London
1997 MS Master of Science University of Patras
1995 Dip. Diploma University of Patras
Please report any queries concerning the data shown on this page to:

https://www.ucl.ac.uk/hr/helpdesk/helpdesk_web_form.php
University College London - Gower Street - London - WC1E 6BT Tel:+44 (0)20 7679 2000

© UCL 1999–2011

Search by