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Prof Margaret Ashcroft
G14
Division of Medicine, Rayne Building
5 University Street
London
WC1E 6JF
Tel: 0207 679 0799
Fax: 0207 679 6211
Appointment
  • Div of Medicine
  • Faculty of Medical Sciences
Biography

I undertook my undergraduate (BSc Hons) and postgraduate (PhD) studies at the University of Bristol UK in Pharmacology and Molecular/Cellular Biology respectively, where I was awarded the first BRACE (Bristol Research into Alzheimer’s Disease and Care of the Elderly) PhD studentship. During my PhD, I worked on a novel family of tyrosine receptor kinases (TRKs) which we cloned and characterised in human brain. Upon obtaining my PhD, I moved to the United States to pursue my postdoctoral training at the National Cancer Institute (NCI-FCRDC, Frederick, Maryland). First, under the supervision of David Kaplan, I continued my to work on TRKs and made several key discoveries on the role of TRK-mediated survival via the PI3K signalling pathway. Subsequently, under the supervision of Karen Vousden, I worked on the tumour suppressor protein p53 and its regulator HDM2. In 2001, I moved back to the UK to set up my group as an independent PI at The Institute of Cancer Research (ICR) working on the hypoxia inducible factor (HIF) family of transcription factors, and the interplay between hypoxia signalling, p53 and HDM2. In 2008, I moved to University College London (UCL) and co-founded the Centre for Cell Signalling and Molecular Genetics (CSMG) within the Division of Medicine, which I head. http://www.ucl.ac.uk/cell-signalling.

Research Groups
Research Themes
Research Summary

My research programme primarily focuses on elucidating the key signalling mechanisms regulating the hypoxia inducible factor (HIF) pathway as a basis for gaining a better understanding of the role of HIF in disease (e.g. cancer, renal and cardiovascular diseases, and stroke) and translating our basic research findings by identifying novel therapeutics that target the HIF pathway.

Teaching Summary

Teaching:
2010-current: CR-UK Centre PhD Programme (Cancer Biology, Translational Research, Experimental Cancer Therapeutics, and Clinical Cancer Studies), UCL Cancer Institute, UCL; primary supervisor
2009-current: MSc Clinical and Experimental Medicine, UCL. ‘Targeting the hypoxia-inducible factor pathway as a new therapeutic approach to cancer treatment’ seminars; primary supervisor
2009-current: MSc Cancer Course, UCL. ‘Hypoxia signalling in cancer’ seminars
2009-current: PhD Programme in Drug Discovery, UCL; co-supervisor 
2009-current: BHF PhD Programme in Cardiovascular Biomedicine, UCL; primary supervisor
2007-2008: MSc Medical Oncology Course, ICR. ‘Hypoxia and angiogenesis’ seminars

Appointments
2010 Affiliated Principal Investigator Cancer Research UK and UCL Cancers Centre, UCL Cancer Institute, University College London, United Kingdom
2009 Affiliated Principal Investigator Comprehensive Cancer Centre King’s College London/University College London , United Kingdom
2008 Head, Centre for Cell Signalling and Molecular Genetics Medicine University College London, United Kingdom
2000 – 2008 Group Leader Cancer Research UK Centre for Cancer Therapeutics Institute of Cancer Research, United Kingdom
1997 – 2000 Senior Postdoctoral Researcher- Human Frontiers Fellowship Molecular Carcinogenesis Section NCI-FCRDC, Frederick MD, United States
1995 – 1997 Postdoctoral Researcher Eukaryotic Signal Transduction Section ABL Basic Research Program, NCI-FCRDC, Frederick MD, United States
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