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- Div of Medicine
- Faculty of Medical Sciences
I undertook my undergraduate (BSc Hons) and postgraduate (PhD) studies at the University of Bristol UK in Pharmacology and Molecular/Cellular Biology respectively, where I was awarded the first BRACE (Bristol Research into Alzheimer’s Disease and Care of the Elderly) PhD studentship. During my PhD, I worked on a novel family of tyrosine receptor kinases (TRKs) which we cloned and characterised in human brain. Upon obtaining my PhD, I moved to the United States to pursue my postdoctoral training at the National Cancer Institute (NCI-FCRDC, Frederick, Maryland). First, under the supervision of David Kaplan, I continued my to work on TRKs and made several key discoveries on the role of TRK-mediated survival via the PI3K signalling pathway. Subsequently, under the supervision of Karen Vousden, I worked on the tumour suppressor protein p53 and its regulator HDM2. In 2001, I moved back to the UK to set up my group as an independent PI at The Institute of Cancer Research (ICR) working on the hypoxia inducible factor (HIF) family of transcription factors, and the interplay between hypoxia signalling, p53 and HDM2. In 2008, I moved to University College London (UCL) and co-founded the Centre for Cell Signalling and Molecular Genetics (CSMG) within the Division of Medicine.
My research programme primarily focuses on elucidating the key signalling mechanisms regulating the hypoxia inducible factor (HIF) pathway as a basis for gaining a better understanding of the role of HIF in disease (e.g. cancer, renal and cardiovascular diseases, and stroke) and translating our basic research findings by identifying novel therapeutics that target the HIF pathway.
|01-JUL-2014||Professor||Medicine||University of Cambridge, United Kingdom|
|01-JUL-2014||Honorary Professor||Medicine||University College London, United Kingdom|
|2010||Affiliated Principal Investigator||Cancer Research UK and UCL Cancers Centre,||UCL Cancer Institute, University College London, United Kingdom|
|2009||Affiliated Principal Investigator||Comprehensive Cancer Centre||King’s College London/University College London , United Kingdom|
|2008 – 2014||Head, Centre for Cell Signalling and Molecular Genetics||Medicine||University College London, United Kingdom|
|2000 – 2008||Group Leader||Cancer Research UK Centre for Cancer Therapeutics||Institute of Cancer Research, United Kingdom|
|1997 – 2000||Senior Postdoctoral Researcher- Human Frontiers Fellowship||Molecular Carcinogenesis Section||NCI-FCRDC, Frederick MD, United States|
|1995 – 1997||Postdoctoral Researcher||Eukaryotic Signal Transduction Section||ABL Basic Research Program, NCI-FCRDC, Frederick MD, United States|