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Dr Marco Beato
230
Pharmacology, Medical Sciences Building
UCL South Cloisters, Gower St
London
WC1E 6BT
Tel: 020 7679 3767
Fax: 020 76797298
Appointment
  • Reader in Neuroscience
  • Neuro, Physiology & Pharmacology
  • Div of Biosciences
  • Faculty of Life Sciences
Biography

I graduated in 1995 with a degree in theoretical physics from the University “La Sapienza” in Rome. I obtained a PhD in Biophysics from the International School for Advanced Studies (SISSA/ISAS, Trieste-Italy) in 1999. I started my post-doctoral work at the School of Pharmacy in the lab of Dr Lucia Sivilotti and moved to UCL in 2001 with a MRC Training Research Fellowship. In 2005 I was awarded a Wellcome Trust Career Development Award and a Royal Society University Research Fellowship for continuing my studies on glycinergic transmission in the spinal cord.

Research Groups
Research Themes
Research Summary
My current research is focussed on the characterization of premotor interneurons in the ventral horn of the spinal cord. Premotor networks are involved in all motor circuits and are responsible for the coordination of locomotor activity and for the execution and tuning of all motor tasks.

My main aim is to describe the properties of the network of premotor interneurons in relation to their function and to characterize individual synaptic connections.

In the past I have studied the kinetic of glycine receptors using single channel recordings and fast concentration jumps techniques, combined with mathematical modeling and kinetic analysis. Now I am using electrophysiological recordings to record from multiple cells and from synaptically connected interneuron-motoneuron pairs in slices or in the en-bloc spinal cord.

In collaboration with Professors Andrew Todd and David Maxwell (University of Glasgow) we have characterized glycinergic premotor interneurons and measured the strength of Renshaw cells synapses onto motoneurons. We will now use a rabies based trans-synaptic tracer to label networks of flexor and extensor related premotor interneurons and to drive the expression of channelrhodopsin. Our aim is to determine a map of functional connectivity and to relate it to the electrophysiological and neurochemical profiles of premotor interneurons.

Quantal analysis methods and kinetic modeling are used to characterize the properties of synapses.

My work is funded by a Royal Society University Research Fellowship, by the Leverhulme Trust and by a BBSRC project grant (joint with the University of Glasgow).

Teaching Summary

I regularly give lectures and tutorials on several courses within the Pharmacology and Neuroscience degree programmes, including modules PHAR1001, PHAR2003 and PHOL2006. I organize and assist in the preparation of 6 practical modules.

Appointments
01-OCT-2010 – 30-SEP-2013 Royal Society Senior University Research Fellow NPP UCL, United Kingdom
01-OCT-2005 – 30-SEP-2010 Royal Society University Research Fellow NPP UCL, United Kingdom
01-OCT-2002 – 30-SEP-2005 MRC Training Research Fellow NPP UCL, United Kingdom
Academic Background
1999 PhD Doctor of Philosophy – Biophysics Scuola Internazionale Superiore di Studi Avanzati di Trieste
1994 DipLaurea Diploma di Laurea – Physics Universita degli Studi di Roma La Sapienza
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