UCL  IRIS
Institutional Research Information Service
UCL Logo
Please report any queries concerning the funding data shown on the profile page to:

http://www.ucl.ac.uk/finance/secure/research/post_award
Please report any queries concerning the student data shown on the profile page to:

Email: portico-services@ucl.ac.uk

Help Desk: http://www.ucl.ac.uk/ras/portico/helpdesk
 More search options
Dr Marilena Loizidou
Academic Department of Surgery, UCL Medical School
9th floor, Royal Free Hospital
London
NW3 2QG
Tel: 020 7794 0500 x 35575; x35303
Appointment
  • Senior Lecturer
  • Research Department of General Surgery
  • Div of Surgery & Interventional Sci
  • Faculty of Medical Sciences
 
 
Research Summary
COLORECTAL CANCER: We have delineated cellular and molecular mechanisms and mapped overexpression of a growth promoting peptide (Endothelin-1) and its receptor (Endothelin A receptor). We evaluated endothelin A receptor antagonism as a novel treatment agent and demostrated cancer killing. Agents (against endothelin A receptors) are being entered in clinical trials of patients with advanced colorectal cancer. The aim is to provide effective drug treatments for advanced colorectal cancer. MULTIDRUG RESISTANT CANCERS (breast and bladder): We have described a novel drug delivery system: photochemical internalisation of chemotherapy. This involves delivery of chemotherapeutics in an endosome whose membrane contains photodynamic agents. The latter are activated upon illumination resulting in the endosomal membrane bursting and chemotherapeutic agent delivered intracellularly. Other nanoscale drug delivery systems are also under investigation. The aim is to bypass drug-resistance which tends to develop in the majority of solid cancers. REGENERATIVE MEDICINE: We are constructing a nanopolymer based scaffold for the small intestine. The scaffold incorporates different cell types and will encourage nerve regeneration and the production of a blood supply. The ultimate aim is to tissue engineer tissue to treat small bowel syndrome.
Teaching Summary
CURRENT: (a) (Co)Creator and Tutor of the intercalated BSc in Surgical Sciences; (b)(Co)Creator and Tutor of the MSc in Nanotechnology and Regenerative Medicine; (c) Module Organiser for the MSc in Surgical Sciences PAST ACTIVITIES: (Co)Creator of the intercalated BSc in Tumour Biology
Appointments
2000 Senior Lecturer    , United Kingdom
Academic Background
1991 PhD Doctor of Philosophy University of Southampton
1985 MSc Master of Science University of Southampton
1984 BSc Bachelor of Science McMaster University
Please report any queries concerning the data shown on this page to:

https://www.ucl.ac.uk/hr/helpdesk/helpdesk_web_form.php
University College London - Gower Street - London - WC1E 6BT Tel:+44 (0)20 7679 2000

© UCL 1999–2011

Search by