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Dr Matthew Gegg
3B-101
Royal Free Medical School, Upper 3rd Floor
Rowland Hill Street
London
NW3 2PF
Tel: 020 7794 0500 35354
Appointment
  • Senior Research Associate
  • Clinical Neuroscience
  • Institute of Neurology
  • Faculty of Brain Sciences
Research Summary
Mutations in the gene encoding for glucocerebrosidase are the greatest known genetic risk factor for developing Parkinson's disease. Glucocerebrosidase is a lysosomal enzyme involved in sphingolipid metabolism. Impairment of the autophagy-lysosomal pathway is implicated in the accumulation/aggregation of alpha-synuclein and the mitochondrial dysfunction observed in Parkinson's disease. I am investigating the mechanisms by which glucocerebrosidase deficiency contributes to aberrant function of the autophagy-lysosome pathway.
Academic Background
1999 PhD Doctor of Philosophy – Neurochemistry University College London
1997 BSc Hons Bachelor of Science (Honours) – Biochemistry University of Bath
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