UCL  IRIS
Institutional Research Information Service
UCL Logo
Please report any queries concerning the funding data shown on the profile page to:

http://www.ucl.ac.uk/finance/secure/research/post_award
Please report any queries concerning the student data shown on the profile page to:

Email: portico-services@ucl.ac.uk

Help Desk: http://www.ucl.ac.uk/ras/portico/helpdesk
 More search options
Dr Matthew Reeves
Institute of Immunity & Transplantation
Royal Free Campus
Hampstead
London
NW3 2PF
Tel: 0207794 0500 ext 33109
Appointment
  • Senior Lecturer
  • Div of Infection & Immunity
  • Faculty of Medical Sciences
Biography

My PhD studies in the laboratory of Profs. Sinclair and Sissons (University of Cambridge) centred on defining dendritic cells as sites of HCMV reactivation and the contribution chromatin structure made to controlling the transition from latency to reactivation. I continued my post-doctoral training with John Sinclair during which time we characterised the anti-apoptotic function of a virally encoded untranslated RNA, Beta 2.7. I then moved to the US and Novartis Institute for Biomedical Research (Cambridge, MA) on an academic fellowship to work with Prof. Teresa Compton where i developed an interest in signalling pathways and the contribution they made to successful viral entry into a latent cell. 

I then returned to the UK (University of Cambridge) on an MRC CDA Fellowship to investigate the role of cellular signalling pathways in HCMV reactivation and the contribution viral proteins expresse during latency made to this process. I transferred my fellowship to the newly created Institute of Immunity & Transplantation to begin to develop these themes in a more experimental medicine setting and to take up a proleptic appointment to Senior Lecturer at the end of my MRC fellowship.

Research Summary
Human cytomegalovirus (HCMV) is an opportunistic pathogen that is a significant cause of morbidity and mortality in immune-compromised individuals. Like all herpesviruses, HCMV establishes a lifelong latent infection in the host and a major site of latency is the cells of the myeloid lineage; latency being established in a sub-population of CD34+ progenitor cells in the bone marrow. Only upon normal differentiation of these cells to macrophages or dendritic cells (DCs) is reactivation detected. Consequently, it is hypothesised that changes in the cellular environment concomitant with differentiation also promote reactivation.

It is becoming increasingly clear that throughout latency (from establishment to maintenance and, ultimately, reactivation) there is a complex interplay between the virus and the cell. Our own studies are mainly focussed on the events that occur at the point of entry into the cellular site of latency and the mechanisms that trigger reactivation. In both instances, we are interested in the role of cellular signalling and, furthermore, the viral mechanisms that contribute to the successful utilisation of these cellular pathways.

Through these studies we hope to further our understanding of the complex interaction between the host and pathogen and,specifically, the intimate relationship persistent viruses have with their host. It is envisaged these studies will also provide the basis for the development of novel therapeutic strategies.

 

Teaching Summary
My laboratory supports undergraduate and graduate students (Masters & PhD students)
I lecture on the final year virology course 
I also co-organise the data Interpretation Module on the UCL M.Sc course in Infection & Immunity
Academic Background
2005 PhD Doctor of Philosophy University of Cambridge
2000 BSc Hons Bachelor of Science University of Manchester
Please report any queries concerning the data shown on this page to:

https://www.ucl.ac.uk/hr/helpdesk/helpdesk_web_form.php
University College London - Gower Street - London - WC1E 6BT Tel:+44 (0)20 7679 2000

© UCL 1999–2011

Search by