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- Senior Lecturer
- Div of Infection & Immunity
- Faculty of Medical Sciences
My PhD studies in the laboratory of Profs. Sinclair and Sissons (University of Cambridge) centred on defining dendritic cells as sites of HCMV reactivation and the contribution chromatin structure made to controlling the transition from latency to reactivation. I continued my post-doctoral training with John Sinclair during which time we characterised the anti-apoptotic function of a virally encoded untranslated RNA, Beta 2.7. I then moved to the US and Novartis Institute for Biomedical Research (Cambridge, MA) on an academic fellowship to work with Prof. Teresa Compton where i developed an interest in signalling pathways and the contribution they made to successful viral entry into a latent cell.
I then returned to the UK (University of Cambridge) on an MRC CDA Fellowship to investigate the role of cellular signalling pathways in HCMV reactivation and the contribution viral proteins expresse during latency made to this process. I transferred my fellowship to the newly created Institute of Immunity & Transplantation to begin to develop these themes in a more experimental medicine setting and to take up a proleptic appointment to Senior Lecturer at the end of my MRC fellowship.
It is becoming increasingly clear that throughout latency (from establishment to maintenance and, ultimately, reactivation) there is a complex interplay between the virus and the cell. Our own studies are mainly focussed on the events that occur at the point of entry into the cellular site of latency and the mechanisms that trigger reactivation. In both instances, we are interested in the role of cellular signalling and, furthermore, the viral mechanisms that contribute to the successful utilisation of these cellular pathways.
Through these studies we hope to further our understanding of the complex interaction between the host and pathogen and,specifically, the intimate relationship persistent viruses have with their host. It is envisaged these studies will also provide the basis for the development of novel therapeutic strategies.
|2005||PhD||Doctor of Philosophy||University of Cambridge|
|2000||BSc Hons||Bachelor of Science||University of Manchester|