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Dr Matthew Reeves
Institute of Immunity & Transplantation
Royal Free Campus
Tel: 0207794 0500 ext 33109
  • Senior Lecturer
  • Div of Infection & Immunity
  • Faculty of Medical Sciences

PhD: The regulation of human cytomegalovirus latency and reactivation in dendritic cells by chromatin remodelling. University of Cambridge (Profs. Sissons & Sinclair)

Post Doctoral Associate: the anti-apoptotic function of virally expressed untranslated RNA. University of Cambridge (Prof. Sinclair)

Presidential Fellowship: Cellular signalling in HCMV latency and reactivation. Novartis, Massachussets, USA (Prof. Compton)

MRC CDA Fellowship: Impact of cellular signalling and viral gene expression of reactivation of HCMV from latency (University of Cambridge/ UCL)

Senior Lecturer: Institute of Immunity & Transplantation, UCL.

Research Summary
Human cytomegalovirus (HCMV) is an opportunistic pathogen that is a significant cause of morbidity and mortality in immune-compromised individuals. Like all herpesviruses, HCMV establishes a lifelong latent infection in the host and a major site of latency is the cells of the myeloid lineage; latency being established in a sub-population of CD34+ progenitor cells in the bone marrow. Only upon normal differentiation of these cells to macrophages or dendritic cells (DCs) is reactivation detected. Consequently, it is hypothesised that changes in the cellular environment concomitant with differentiation also promote reactivation.

It is becoming increasingly clear that throughout latency (from establishment to maintenance and, ultimately, reactivation) there is a complex interplay between the virus and the cell. Our own studies are focus on events that occur during the very early stages of viral entry into the cellular site of latency and the mechanisms that trigger reactivation. In both instances, we are interested in the reliance of host signalling pathways for these processes  and, furthermore, the viral mechanisms that contribute to the successful utilisation of these cellular pathways.

Through these studies we hope to further our understanding of the complex interaction between the host and pathogen and,specifically, the intimate relationship persistent viruses have with their host.


Teaching Summary

My laboratory hosts undergraduate and graduate students (Masters & PhD students) and welcomes applications from students who wish to undertake their graduate research with us. Similarly, we host and support undergraduate students applying for summer vacation scholarships.

I lecture on the BSc/MSc Molecular and Advanced Virology courses in Infection & Immunity

I also co-organise and teach the Data Interpretation module for the MSc course in Infection & Immunity

Academic Background
2005 PhD Doctor of Philosophy – Molecular Virology University of Cambridge
2000 BSc Hons Bachelor of Science – Molecular Biology University of Manchester
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