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Dr Mo Keshtgar
Department of Surgery
Royal Free Hospital
Pond Street
Tel: +442078302966
Fax: +442073177608
  • Professor of Cancer Surgery
  • Div of Surgery & Interventional Sci
  • Faculty of Medical Sciences
Research Themes
Research Summary
Mohammed Keshtgar is a Surgical Oncologist with specialist interest in management of breast cancer at the Royal Free and the Whittington campuses. He is leading a number of translational researches in this field: 1. Sentinel Node Biopsy: He is one of the pioneers of this technique in the UK and his work is recognized nationally and internationally. He is the lead author of the first textbook on this subject and has set up a training website for this technique (www.sentienlnode.net). He is the principal investigator of the role of Optical Biopsy in diagnosis of breast cancer in the SLN. This work was the winner of the Medical Futures Cancer Innovation Award in 2008 (http://www.ucl.ac.uk/news/news-articles/0812/08120903). He is leading the Genesearch project for intra-operative diagnosis of SLN. 2. Intra-operative Radiotherapy (IORT) in Breast Cancer (TARGIT Trial): He is the principal investigator of this important trial at the Royal Free Campus and is the member of the International Steering Committee. He is leading cosmesis and quality of life and psychological impact sub-protocols on this trial and is the lead author of a paper on use of IORT in special circumstances. 3. Nanotechnology and Breast Cancer: In collaboration with Prof. Alex Seifalian, he is leading two important projects in this field. I, A near infrared florescent nanotechnology quantum dot for sentinel node localization. II, Development of new generation of breast implants using Silsesquioxane nanocomposit shell. 4. Computer Decision Support System in Breast Cancer Multidisciplinary meetings. He is the principal investigator of this innovative project which utilizes the information technology in making evidence based decision for breast cancer patients that are discussed at the multidisciplinary meetings. We are currently evaluating this innovative and powerful technology in a randomised controlled trial. This project is carried out in collaboration with Prof. John Fox and Dr. Vivek Patkar. 5. Tumour Angiogenesis in Breast Cancer: Correlation between FDG PET, Contrast Enhanced MRI, CT and Histology: He is the PI of this research project (in collaboration with Dr. Ashley Groves and Prof. Peter Ell) which aims to investigate the ability of integrated 18F-FDG PET/contrast enhanced CT and contrast enhanced MRI to assess tumour angiogenesis in patients with breast cancer. 6. Photodynamic Therapy (PDT) in Management of Primary Breast Cancer He is the chief investigator of this phase I / IIa study in patients diagnosed with primary breast cancer. PDT involves intravenously injecting the photosensitizer drug that has affinity to malignant cells. This drug makes the tumour sensitive to light. A non-thermal light is shone in the tumour, which brings about tissue necrosis (destruction).
Teaching Summary
He is the National Trainer on Sentinel Node Biopsy on behalf of the Royal College of Surgeons of England and has trained in excess of 500 healthcare professionals on this area (http://www.ucl.ac.uk/news-archive/archive/2004/june-2004/latest/newsitem.shtml?04060118) . He advisor to the IAEA on training this technique and has run several international workshops. He also is a trainer on Intra-operative Radiotherapy for Breast Cancer Management. He leads a Special Study Module on Breast Cancer for undergraduate medical students and is the recipient of Distinguished Teacher Award and Certificate of Teaching Excellence in Surgery from UCL.
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