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Dr Masazumi Tada
Rm 105, Anatomy building
Department of Cell & Developmental Biology, UCL
Gower Street
London
WC1E 6BT
Appointment
  • Reader in Developmental and Cellular Biology
  • Cell & Developmental Biology
  • Div of Biosciences
  • Faculty of Life Sciences
Research Groups
Research Themes
Research Summary
I am interested in cellular and molecular mechanisms underlying co-ordinated and directional cell movements. The primary focus is on morphogenetic movements occurring during gastrualtion using the zebrafish as a model system; epiboly, convergence/extension and anterior migration of mesodermal cells. Since we showed that Wnt11 is an important regulator of convergence/extension movements during gastrulation in vertebrates, it has been evident that this ligand acts in a pathway related to the planar cell polarity (PCP) pathway in Drosophila. Recently, the core PCP genes have been also implicated in regulating a variety of morphogenetic processes in vertebrates including neural tube closure, orientation of cochlear hair cells, migration of facial motorneurons and ciliogenesis. Current projects are a) Understanding mechanisms by which core PCP proteins regulate gastrulation movements in zebrafish; b) Identifying and characterising genetic pathways that act in or in parallel with the PCP pathway during gastrulation; c) Exploring other biological processes that are regulated by the PCP genes and their genetic modifiers.
Academic Background
1990 PhD Doctor of Philosophy – Applied Biochemistry University of Tsukuba
1986 MSc Master of Science – Physical Sciences University of Tsukuba
1983 BSc Bachelor of Science – Applied Biochemistry University of Tsukuba
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