My research interests are focussed on the early detection, differential diagnosis and monitoring of progression in cognitive disorders and neurodegenerative dementias in particular. My particular interest within this broad grouping has been in the use of MRI to improve diagnosis and to measure progression in Alzheimer's disease and related disorders. I have been involved in the use of automated measures of cerebral atrophy derived from serial MRI to assess treatment efficacy and disease-modifying potential of novel therapies. I also have a particular interest in the familial dementias and the use of biomarkers and clinical and cognitive measures to assess the earliest manifestations of autosomal dominant dementias, both Alzheimer's disease and frontotemporal lobar degenerations.