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Dr Nicholas Keep
Department of Crystallography, Birkbeck College
Malet Street
London
WC1E 7HX
Tel: 020 7631 6852
Fax: 020 7631 6803
Appointment
  • Honorary Lecturer
  • Structural & Molecular Biology
  • Div of Biosciences
  • Faculty of Life Sciences
Research Themes
Research Summary
My research is primarily in structural biology of disease, recently particularly tuberculosis. My neurological interests are in neuromuscular disorders in particular muscular dystrophies, where I have worked on utrophin and dystrophin and dysferlin and myoferlin. These studies have resulted in the structures of the actin binding regions of utrophin and dystrophin and in the Fer domain of the ferlins. The interest in dystrophin, which is involved in linking plasma membrane proteins to the cytoskeleton has extended to other proteins linking intrinsic membrane proteins and the cytoskeleton, including the FERM family protein moesin and GABARAP, a protein that is reported to link GABA receptors to tubulin, but is more likely to be involved in trafficking and regulation of the GABA receptor. My primary technique is protein crystallography, but with colleagues in the ISMB I also use NMR and electron microscopy as is most appropriate to the protein of interest.
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