Help Desk: http://www.ucl.ac.uk/ras/portico/helpdesk
- Professor of Molecular Medicine
- ICH - Experimental & Personalised Med
- Genetics & Genomic Medicine
- Faculty of Population Health Sciences
Our goal is to elucidate the genetic and developmental basis of congenital malformations. Previous and current work indicates that this can uncover novel genetic mechanisms and offer insights into general mechanisms of development and even common disease. For instance, the deletion 22q11 casuing DiGeorge syndrome is the greatest known genetic risk factor for schizophrenia. Clinical and diagnosis and prognosis can be improved, and in some cases there is the prospect of new therapeutic intervention. Two genes under investigation (Tbx1 and Hira) have roles in progenitor or stem cell populations.
The tools used include creation and analysis of models in mouse and zebrafish. We explore novel methods of imaging the phenotypes observed (in collaboration with UCL's CABI). In humans, genetic approaches include high resolution, genome-wide, screens and sequencing, in particular making use of consanguineous families. We also collaborate across non-life science faculties via the CoMPLEX programme.
I manage two 4 year PhD programmes with the first intake being October 2009, and the last intake 2012.
One is run through UCL CoMPLEX and is specifically designed to bring non-life scientists and cardiovascular biologists together for innovative projects. The first year of this course is essentially the same as that for all CoMPLEX students.
The second is for more standard, biologically orientated PhDs. The first year is run alongside the UCL-ICH MRes scheme.
|1986||MD||Doctor of Medicine||University of Manchester|
|1982||MB.ChB||Bachelor of Medicine, Bachelor of Surgery||University of Manchester|
|1979||BSc Hons||Bachelor of Science (Honours)||University of Manchester|