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- Professor of Respiratory Cell and Molecular Biology
- Internal Medicine
- Div of Medicine
- Faculty of Medical Sciences
Professor Chambers received her undergraduate degree (BSc Biology) from King’s College London and completed her PhD in Biochemistry at the National Heart and Lung Institute in London in 1995. Her early post-doctoral studies were supported by a personal Wellcome Trust Post-doctoral fellowship with her time divided between UCL and Roche Bioscience (Palo Alto, USA). Upon returning to the UK in 1997, she began to build an independent research programme and was appointed HEFCE Lecturer within the Division of Medicine at UCL in 1998. She was promoted to Senior Lecturer in 2002, Reader in 2006 and Professor in 2009. She took on the role of Director of the Centre for Inflammation and Tissue Repair within the UCL Division of Medicine in 2012 and was appointed Vice-Dean (Enterprise) of the Faculty of Medical Sciences in 2013.
Professor Chambers is Director of the Centre for Inflammation and Tissue Repair and is also Vice-Dean (Enterprise) for the UCL Faculty of Medical Sciences. Her research programme is focused on identifying the key cellular mechanisms and signalling pathways involved in driving lung injury, inflammation and fibrosis, with a particular emphasis on the role of the proteinase-activated receptors (PARs) and the TGF-β signalling axis. This research programme is based within the clinical settings of acute respiratory distress syndrome, pulmonary fibrosis and airway remodelling and integrates fundamental studies in cell, tissue and disease model systems through to translational studies in humans. Professor Chambers’ group encompasses an active and dynamic mix of scientists, clinician scientists and PhD students and is supported by grants obtained from major funding agencies, including The Medical Research Council, The British Lung Foundation, The Wellcome Trust and The Rosetrees Trust.
Professor Chambers has a keen interest in Enterprise and also directs a discovery biology group at UCL as part of a major academic-industry alliance with GlaxoSmithKline (GSK) in the area of fibrosis. The industry partnership lead for this programme is Dr Paul Mercer, a senior Research Associate with extensive expertise in novel drug target identification and validation. Professor Chambers has also has recently established a small research team in order to prosecute novel targets in the context of neutrophilic inflammation at the Stevenage Bioscience Catalyst (SBC). The SBC innovation lead for this initiative is Dr Andrew Williams, who has a longstanding track-record in lung inflammation and immunology.
Professor Chambers is passionate about training and nurturing future biomedical research leaders. She has successfully supervised ten PhD students as primary supervisor and four PhD students as secondary supervisor. She has also sponsored a number of successful pre-and post-doctoral fellowship applications. In 2004, she took on the role of Divisional Postgraduate Tutor within the Division of Medicine and served in this role until 2013. She has acted as external examiner for over 20 PhD examinations both within and outside the UK.
|PhD||Doctor of Philosophy – Biochemistry||University of London|