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Dr Rickie Patani
The Francis Crick Institute
1 Midland Road, Floor 2 (SE quadrant)
London
NW1 1AT
Appointment
  • Wellcome Trust Intermediate Clinical Fellow
  • Molecular Neuroscience
  • Institute of Neurology
  • Faculty of Brain Sciences
Biography
Rickie Patani obtained his BSc (in Cellular and Molecular Neuroscience) and MBBS from Imperial College London in 2004. He gained MRCP in 2007 and a PhD in Stem Cell Neurobiology from Cambridge University in 2011, funded by a Wellcome Trust Clinical Research Fellowship. While completing his higher clinical training in Neurology, he was awarded a Wellcome Trust Clinician Scientist Fellowship and started his research group at the Department of Molecular Neuroscience at the UCL Institute of Neurology in 2013. Rickie gained MRCP (Neurology) in 2015 and was appointed as an Honorary Consultant Neurologist at the National Hospital for Neurology and Neurosurgery, Queen Square in 2017. Rickie's lab will shortly move to the Francis Crick Institute, where they will continue to work on human induced pluripotent stem cell models of neurodegeneration, with particular focus on the themes of RNA metabolism and cellular autonomy. Rickie's lab has a diverse portfolio of public engagement activities (see the group's twitter account @PataniLab for more information).

Research Summary

The generation of clinically relevant and highly specialized human cell populations provides an unprecedented opportunity to study development and disease of the human nervous system in a petri-dish. My research laboratory uses human pluripotent stem cell technology to molecularly define the precise roles of RNA metabolism and cellular autonomy in the pathogenesis of motor neuron disease (MND) and other neurodegenerative disorders. In order to robustly investigate initiating molecular events, we employ disease-specific human induced pluripotent stem cells, together with novel functional genomic methodologies (developed in Professor Jernej Ule’s lab), to elucidate post-transcriptional mechanisms of neurodegeneration. This work will begin to resolve the molecular pathogenesis of MND in order to guide a more mechanistically rationalised therapeutic strategy for this rapidly progressive and untreatable condition.

Appointments
04-SEP-2017 Group Leader at the Francis Crick Institute   The Francis Crick Institute, United Kingdom
16-MAR-2017 Honorary Consultant Neurologist at NHNN, Queen Square Clinical Neurology The National Hospital for Neurology, Queen Square, United Kingdom
Academic Background
2011 PhD Doctor of Philosophy – Cell and Developmental Biology University of Cambridge
2007 MRCP Member of the Royal College of Physicians – Medicine Royal College of Physicians
2004 MBBS Bachelor of Medicine/Bachelor of Surgery – Medicine Imperial College of Science, Technology and Medicine
2002 BSc Hons Bachelor of Science – Neuroscience and Medical Science Imperial College of Science, Technology and Medicine
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