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Dr Rickie Patani
The Francis Crick Institute
1 Midland Road, Floor 2 (SE quadrant)
London
NW1 1AT
Appointment
  • MRC Senior Clinical Fellow
  • Department of Neuromuscular Diseases
  • UCL Queen Square Institute of Neurology
  • Faculty of Brain Sciences
Biography
Rickie Patani obtained a BSc (in Cellular and Molecular Neuroscience) and MBBS from Imperial College London in 2004. He gained MRCP (UK) in 2007 and a PhD in Stem Cell Neurobiology from Cambridge University in 2011, funded by a Wellcome Trust Clinical Research Fellowship. While completing his higher clinical training in Neurology, he was awarded a Wellcome Trust Intermediate Clinical Fellowship to start his independent research group at UCL Queen Square Institute of Neurology from 2013. Rickie gained MRCP (Neurology) in 2015 and was subsequently appointed Honorary Consultant Neurologist at the National Hospital for Neurology, Queen Square. Rickie was appointed Group Leader at the Francis Crick Institute in 2016, where his research group continue to work on human induced pluripotent stem cell models of motor neuron disease (ALS), with particular focus on the themes of RNA metabolism and cellular autonomy. He was appointed Associate Professor at UCL Queen Square Institute of Neurology in 2017, and subsequently elected Fellow of the Royal College of Physicians (FRCP). In 2018, Rickie was awarded an MRC Senior Clinical Fellowship to continue his group’s work on the cellular and molecular mechanisms underlying ALS. The Patani lab has a diverse portfolio of public engagement activities (see the group's twitter account @PataniLab for more information).

Research Summary

The generation of clinically relevant and highly specialized human cell populations provides an unprecedented opportunity to study development and disease of the human nervous system in a petri-dish. My research laboratory uses human pluripotent stem cell technology to molecularly define the precise roles of RNA metabolism and cellular autonomy in the pathogenesis of motor neuron disease (MND) and other neurodegenerative disorders. In order to robustly investigate initiating molecular events, we employ disease-specific human induced pluripotent stem cells, together with novel functional genomic methodologies (developed in Professor Jernej Ule’s lab), to elucidate post-transcriptional mechanisms of neurodegeneration. This work will begin to resolve the molecular pathogenesis of MND in order to guide a more mechanistically rationalised therapeutic strategy for this rapidly progressive and untreatable condition.

Appointments
01-DEC-2018 – 30-NOV-2023 MRC Senior Clinical Fellowship ION UCL and The Francs Crick Institute, United Kingdom
01-OCT-2018 Associate Professor (Principal Research Fellow)   UCL Queen Square ION, United Kingdom
04-SEP-2017 Group Leader at the Francis Crick Institute   The Francis Crick Institute, United Kingdom
16-MAR-2017 Honorary Consultant Neurologist at NHNN, Queen Square Clinical Neurology The National Hospital for Neurology, Queen Square, United Kingdom
01-OCT-2013 – 30-NOV-2018 Wellcome Trust Intermediate Clinical Fellowship ION UCL and The Francis Crick Institute, United Kingdom
Academic Background
2018 FRCP Fellow of the Royal College of Physicians – Neurology Royal College of Physicians
2017 CCST Certificate of Completion of Specialist Training – Neurology General Medical Council
2015 SPCERT Specialty Certificate – Neurology Royal College of Physicians
2011 PhD Doctor of Philosophy – Cell and Developmental Biology University of Cambridge
2007 MRCP Member of the Royal College of Physicians – Medicine Royal College of Physicians
2004 MBBS Bachelor of Medicine/Bachelor of Surgery – Medicine Imperial College of Science, Technology and Medicine
2002 BSc Hons Bachelor of Science – Neuroscience and Medical Science Imperial College of Science, Technology and Medicine
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