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Dr Rahul Phadke
Division of Neuropathology
Institute of Neurology
London
UK
WC1N 3BG
Appointment
  • Honorary Senior Research Associate
  • Institute of Neurology
  • Faculty of Brain Sciences
Biography

I was appointed in the permanent post as Consultant Neuropathologist at the National Hospital for Neurology and Neurosurgery in 2010 and Honorary Senior Research Associate in the Department of Molecular Neuroscience, UCL. I trained as a SpR in Neuropathology in the Division from 2005-2009. Prior to specialist neuropathology training, I trained as a General Pathologist in London and Mumbai, India.

In my present role, I lead the paediatric muscle biopsy service for the Dubowitz Neuromuscular Centre along with Professor Caroline Sewry. We are currently the largest paediatric neuromuscular service in the United Kingdom. In the years 2011-12 and 2012-13, we reported ca. 300 cases annually. Our service includes the NSCT designated referral service for congenital myopathies and congenital muscular dystrophies. My specialist diagnostic and research interest focusses on the paediatric neuromuscular disorders, and I have research collaborations with colleagues at the DNC and other groups in UCL covering the above themes. I also have a special interest in diagnostic peripheral nerve pathology. A business case for establishing a diagnostic skin biopsy service for small fibre neuropathies led by myself in the Division is being developed and we aim to roll this out in early 2014.
I contribute to diagnostic surgical neuropathology reporting including brain biopsies and neurological post mortems (hospital and coronial). I also contribute to teaching and training of medical undergraduates, researchers and post graduate trainees.

Research Summary

My research focusses on congenital myopathies and congenital muscular dystrophies in collaboration with neuromuscular colleagues at the DNC. Other on-going/completed projects in 2012-13 include: · Spectrum of mitochondrial changes in paediatric muscle related to development and mitochondrial disease (Dr Andrea Cortese, Milan) · FACS quantitation in dystroglycanopathies and collagenopathies (DNC/ICH colleagues) · The role of mitochondrial biogenesis in muscle function recovery in critical illness (Dr Saima Saeed, Dr Neil Hill, Professor Mervyn Singer, UCL) · Pathophysiology of acute skeletal muscle wasting in critical illness (Dr Zudin Puthucheary, UCL)

I have over 20 publications in peer reviewed journals and I am a reviewer for Neuromuscular Disorders, Neuropathology and Applied Neurobiology, Skull Base and Cytopathology. 

Teaching Summary

I am the Neuropathology Educational Lead for year 4 medical undergraduates rotating at Queen Square. We have developed a comprehensive one hour teaching module for students encompassing microscopy slide sessions and brain dissections. I regularly lecture on muscle pathology at various national and international teaching courses and by invitation. I have contributed to the E-brain resource. I am actively involved in providing muscle pathology training for national and international visitors to the Dubowitz Neuromuscular Centre and the Division of Neuropathology. I have recently contributed to the Muscle chapter in the latest edition of Greenfield’s Neuropathology and to the ‘Queen Square Text Book’. 

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