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Dr Spyridon Gerontas
UCL Biochemical Engineering
Bernard Katz Building
Tel: 020767937745
  • Research Associate
  • Dept of Biochemical Engineering
  • Faculty of Engineering Science
Research Summary

I am a biochemical engineer with expertise in the mathematical modelling of bioprocess unit operations currently employed as a Post-Doctoral Research Associate in the EPSRC Centre for Innovative Manufacturing in Emergent Macromolecular Therapies hosted at the Department of Biochemical Engineering, UCL.

After completing my undergraduate studies in Chemical Engineering at the National Technical University of Athens, Greece, I conducted postgraduate studies at the Department of Biochemical Engineering at University College London, UK. My doctorate focused on the field of tissue engineering. I developed mathematical models to predict the mass transfer requirements of a prototype bioreactor for the formation of tissue-engineered arteries. Novel ultra scale-down experiments were conducted to determine the parameters needed for such models using small quantities of cells. Additionally, I enhanced my knowledge in computational fluid dynamics and mathematical programming as well as in laboratory techniques most notably human cell culture, 3D cell culture, flow cytometry and oxygen / pH optical sensing.

My background and research interests lie in chromatography, computational fluid dynamics (CFD), design of experiments (DoE), mass transfer and tissue engineering.  My main area of research is the development of chromatographic mechanistic models from high throughput data to predict large scale purification. Windows of Operation for the large scale are then generated indicating the contours for different protein yield and throughput targets as a function of the critical process parameters (e.g. protein load, linear velocity).

Currently, I focus on the feasibility of mixed-mode chromatography to purify Fab antibody from E. coli homogenised feed using a non-affinity three-step process. The feasibility study involves the screening of five commercial resins per chromatographic step as potential candidates using high-throughput process screening based on DoE approach. As part of this study, I direct a small team of master students to design a sequence of chromatographic steps starting with mixed-mode as capture step, cation and anion exchange as polishing steps.

I am also the award manager of a grant sponsored by GE Healthcare, Uppsala, Sweden on the experimental and theoretical investigation of a new chromatographic modular cartridge concept for scavenging and capture applications. The novelty of the concept lies in the combination of dried standard chromatography resins with a pre-packed cartridge design to achieve scalability with respect to chromatographic efficiency and to size an installation to the capacity required at the point of use. 

Academic Background
2007 PhD Doctor of Philosophy – Biochemical Engineering University College London
2000 BSc Bachelor of Science – Chemical Engineering National Technical University of Athens
2000 MSc Master of Science – Chemical Engineering National Technical University of Athens
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