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- Research Fellow
- Institute of Cardiovascular Science
- Faculty of Pop Health Sciences
Tina’s background is in genetics, having completed an undergraduate degree in Human Genetics at UCL, and going on to attain a PhD in Professor Hingorani’s laboratory in cardiovascular genetics. The focus of her PhD was in evaluating the role of C-reactive protein in the prediction and pathogenesis of coronary disease. During her PhD and postdoctoral work, she has focussed on a number of genetic and epidemiological approaches, including integrating information on genotype and/or phenotypes (including detailed information on blood biomarkers) in large population studies using meta-analysis, to address several fundamental issues in cardiovascular disease (CVD) including:
- the utility of certain novel biomarkers (including CRP) for prediction of CVD events
- the causal relevance of certain novel biomarkers in atherosclerosis and CVD
- the mechanisms underlying the associations between
single nucleotide variation and CVD risk uncovered recently by genome wide
association studies (GWAS)
Tina continues to pursue her interest in cardiovascular genetics as a postdoctoral fellow in the Genetic Epidemiology group, utilising relevant genetic and epidemiological approaches. She is now part of the University College-London School-Edinburgh-Bristol (UCLEB) Consortium, investigating genes and biomarkers involved in cardiovascular disease. The unique properties of the UCLEB Consortium provide an opportunity to investigate genetic determinants of risk factors for CVD through Metabochip-wide association analyses (MWAs), as well as associations with measures of subclinical disease such as carotid intima media thickness (cIMT), and with clinical events. Integration of genotype, biomarker and disease outcome data can also provide insight into disease mechanisms and potential therapeutic targets.
Tina teaches on the MSc course GENEG002 Cardiovascular Genetics.
|2007||PhD||Doctor of Philosophy – Medicine||University College London|
|2002||BSc||Bachelor of Science – Human Genetics||University College London|