My research is currently focussed on two broad themes: 1. Leading the development of a research programme in Adolescent Rheumatology. This involves the creation of 'research' pathways that interface between the paediatric and adult research centres at UCL to allow for streamlined transitional research in adolescents with arthritis that spans the whole adolescent age range. Translational basic science projects in autoimmune rheumatic diseases that target adolescents such as enthesitis related arthritis and juvenile onset systemic lupus erythemotsus are being targeted in particular. Also clinical trials in adolescents are now being set up at UCL/UCLH as well as active engagement in National Cohort Studies. 2. Basic science research into the pathogenesis of the antiphospholipid syndrome (APS) and lupus. I am co-PI on an Arthritis Research UK Programme grant that is investigating various molecular pathways that mediate pathogenesis in APS as well as partnering with a Biotech company to develop a novel recombinant peptide as a therapeutic. The mechanisms of cardiac injury are also being explored in lupus with a project investigating the relevance of ischemic-reperfusion injury in this disease.