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Transcatheter Aortic Valve
Due to the increasing ageing population and consequent change in the main heart valve pathology, a growing group of patients is currently declined from surgical valve replacement because they are judged too ill or weak to withstand the stress of invasive treatments. Transcatheter aortic valve implantation (TAVI) represents an ideal answer to the need of this rapidly expanding patients’ population, as it allows delivering a valve substitute into orthotopic position through the endovascular system, avoiding the need of open heart surgery and its associated risks (e.g. cardiac arrest/restart, extracorporeal circulation etc). Clinical experience with this novel approach has clearly indicated that it is feasible and promising, though it still requires substantial design improvements to enhance the safety and effectiveness of the treatment. Dr Burriesci and his team, with the collaboration of Prof Seifalian (Royal Free Hospital), Dr Mike Mullen and Mr John Yap (The Heart Hospital), are currently developing a valve suitable for transcatheter implantation. Recently designed at UCL, this new valve will overcome the main limitations experienced with the other experimented devices. The proposed valve substitute will be fully retrievable/repositionable, will ensure enhanced anchoring and sealing, will maximise expanded/collapsed diameters ratio and extend durability. Moreover, the functional leaflets will be made of a novel synthetic functional nanocomposite polymer suitable for heart valve applications.
2 Researchers
4 External Collaborators
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