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A systems biology approach to dissect the regulation of membrane trafficking by reversible phoshorylation during cell regeneration.
Several billion new cells need to be regenerated every day to maintain proper and efficient function of our body. Improper cellular homeostasis compromises healing, accelerates ageing and is involved in cancer development. Cell replacement is achieved by cell division. A lot of research has focused over the years on the mechanism of chromosomes separation and cell cycle regulation but it was only recently that the importance of membrane trafficking in cell division was appreciated. Reversible phosphorylation is known to control many cellular processes, including cell division and membrane trafficking during interphase. We aim at identifying key proteins regulating membrane trafficking during cell division and at dissecting how phosphorylation potentially regulates them. Because membrane trafficking and cell division are two complex processes involving a number of proteins, we propose to study these systems in a global manner so as to gain a more complete understanding of their mechanisms. We will combine phospho-proteomics, high-throughput screening microscopy with classical biochemistry and cell biology assays to dissect the global mechanisms of phospho-regulation of membrane trafficking during cell division. These studies are expected to contribute to our global understanding of the regulation of cellular membrane exchanges, cell division and cell regeneration.
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