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Stroke Research Group
The Stroke Research Group works in close collaboration with the Hyperacute Stroke Unit (HASU) at University College London Hospital (UCLH) and the Acute Brain Injury Unit based at Queen Square. Stroke is a priority Neuroscience theme within UCL Partners (UCLP), Europe’s largest and strongest academic health science partnership. The UCLP stroke partnership has delivered an effective and efficient clinical stroke network and consolidated hyper-acute services. We have dramatically increased thrombolysis rates and halved the door to needle times for hyper-acute stroke intervention at UCH, creating a network of shared expertise across all acute providers and working directly with community provision. The Stroke Research Group is at the forefront of the development of innovative treatments to prevent stroke, particularly carotid angioplasty and stenting. Professor Martin Brown is the Chief Investigator on two international multicentre randomised trials of the treatment of carotid stenosis, and a member of the Steering and End-point Committees of three other multicentre trials of stroke treatments. The group continues to be involved in research aimed at improving the acute treatment and secondary prevention of stroke - the major cause of adult physical disability in the UK. In addition, our translational research addresses the underlying mechanisms of cerebrovascular disease. We have a particular focus on cerebral microbleeds and small vessel disease, and how these relate to intracerebral haemorrhage and vascular cognitive impairment. In addition to our own projects, the group currently collaborates in a large number of clinical trials and projects and is involved at the planning/approval stage of many others. We recruit patients for participation in studies from the Acute Brain Injury and Stroke Unit (ABIU) at the National Hospital for Neurology and Neurosurgery (NHNN) and the UCLH Trust Hyperacute Stroke Unit, and neurovascular clinics. The Thames Stroke Research Network, based at UCLH is led by Professor Martin Brown, with Dr David Werring the Deputy Lead. The Thames Stroke Research Network has a large and active research portfolio. The network is the largest in the UK, and recruits from around 40 National Institute of Health Research (NIHR) portfolio studies across more than 30 Hospital Trusts. The Thames SRN covers a total population of around 10.5 million and has access to up to 6000 stroke patients per year at the constituent hospitals. The aims of the Thames SRN are to facilitate and develop clinical research in stroke, including randomised trials, and link well organised stroke services with primary care, tertiary care and translational science. Our vision is that we will work together to facilitate the conduct of high quality clinical research and foster the integration of research into clinical practice leading to improved treatment of stroke and its risk factors, which will prevent strokes more effectively and improve outcomes, and thus quality of life for people who have had a stroke and their families.
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