UCL  IRIS
Institutional Research Information Service
UCL Logo
Please report any queries concerning the funding data grouped in the sections named "Externally Awarded" or "Internally Disbursed" (shown on the profile page) to your Research Finance Administrator. Your can find your Research Finance Administrator at http://www.ucl.ac.uk/finance/research/post_award/post_award_contacts.php by entering your department
Please report any queries concerning the student data shown on the profile page to:

Email: portico-services@ucl.ac.uk

Help Desk: http://www.ucl.ac.uk/ras/portico/helpdesk
Headache Group
The Headache Group conducts clinical and laboratory-based research into the mechanisms and management of headache syndromes. The Headache Group has performed seminal functional imaging studies in primary headaches. Functional imaging studies had previously demonstrated specific activation of the brainstem in episodic migraine and the posterior hypothalamus in cluster headache (CH). The group helped further refine the localisation of the brainstem activation in episodic and chronic migraine to the dorsal rostral pons using positron emission tomography (PET) and demonstrated that lateralisation of pain in migraine is due to lateralised brain dysfunction. The group have studied cerebral activation patterns in paroxysmal hemicrania (PH) and short lasting unilateral neuralgiform headache with conjunctival injection and tearing (SUNCT), which along with CH are grouped together as trigeminal autonomic cephalalgias. Significant activation of the posterior hypothalamus and ventral midbrain region was demonstrated in PH using PET while posterior hypothalamic activation was demonstrated in SUNCT using functional magnetic resonance imaging. In a PET study in hemicrania continua (HC), the clinical phenotype of which overlaps with migraine and the trigeminal autonomic cephalalgias, significant activation of the posterior hypothalamus, dorsal rostral pons and ventrolateral midbrain was demonstrated. These series of studies suggested that primary headache may be pathophysiologically differentiated on the basis of distinct patterns of brain activation, with hypothalamic and dorsal pontine activation as markers of trigeminal autonomic cephalalgias and migrainous syndromes, respectively. These studies draw attention to the structures that may play a pivotal role in the pathophysiology of primary headaches.
 More search options
Head of Group
Themes
University College London - Gower Street - London - WC1E 6BT Tel:+44 (0)20 7679 2000

© UCL 1999–2011

Search by