UCL  IRIS
Institutional Research Information Service
UCL Logo
Please report any queries concerning the funding data grouped in the sections named "Externally Awarded" or "Internally Disbursed" (shown on the profile page) to your Research Finance Administrator. Your can find your Research Finance Administrator at http://www.ucl.ac.uk/finance/research/post_award/post_award_contacts.php by entering your department
Please report any queries concerning the student data shown on the profile page to:

Email: portico-services@ucl.ac.uk

Help Desk: http://www.ucl.ac.uk/ras/portico/helpdesk
Mechanisms of disability and recovery in MS
We have focused on optic neuritis as it provides special opportunities to understand the mechanisms of symptom development and recovery. Serial MRI studies of the optic nerve have revealed characteristic time-linked changes in the magnetisation transfer ratio (MTR) and cross-sectional area of the optic nerve. Diffusion tractography has shown abnormalities in the optic radiation that may reflect trans-synaptic degeneration. Abnormal fMRI responses also occur after optic neuritis and simultaneous correlation with structural optic nerve MR measures and visual function suggests that these alterations are adaptive in the acute phase of visual loss. The next phase of the work will include the development of diffusion tractography at higher fields to improve monitoring of white matter tract damage and retinal nerve fibre layer imaging to investigate the relationship between axonal loss, functional effects and MRI in optic neuritis (in collaboration with Mr Ted Garway-Heath, Moorfields Eye Hospital). In addition, we will study the mechanisms of damage in acute lesions that occur in the motor tracts in the brain and cervical spinal cord of MS patients, and, in particular, assess the impact of lesions on the axons which traverse them (Dr Olga Ciccarelli in collaboration with Professor Paul Matthews, Centre for Functional Magnetic Resonance Imaging of the Brain, John Radcliffe Hospital, Oxford)
2 Researchers
 More search options
Head of Group
Themes
University College London - Gower Street - London - WC1E 6BT Tel:+44 (0)20 7679 2000

© UCL 1999–2011

Search by