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Publication Detail
Energy-efficient action potentials in hippocampal mossy fibers.
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Journal Article
  • Authors:
    Alle H, Roth A, Geiger JRP
  • Publication date:
    11/09/2009
  • Pagination:
    1405, 1408
  • Journal:
    Science
  • Volume:
    325
  • Issue:
    5946
  • Status:
    Published
  • Country:
    United States
  • PII:
    325/5946/1405
  • Language:
    eng
  • Keywords:
    Action Potentials, Animals, Axons, Energy Metabolism, Mossy Fibers, Hippocampal, Patch-Clamp Techniques, Potassium, Potassium Channels, Presynaptic Terminals, Rats, Rats, Wistar, Sodium, Sodium Channels, Sodium-Potassium-Exchanging ATPase, Synaptic Transmission
Abstract
Action potentials in nonmyelinated axons are considered to contribute substantially to activity-dependent brain metabolism. Here we show that fast Na+ current decay and delayed K+ current onset during action potentials in nonmyelinated mossy fibers of the rat hippocampus minimize the overlap of their respective ion fluxes. This results in total Na+ influx and associated energy demand per action potential of only 1.3 times the theoretical minimum, in contrast to the factor of 4 used in previous energy budget calculations for neural activity. Analysis of ionic conductance parameters revealed that the properties of Na+ and K+ channels are matched to make axonal action potentials energy-efficient, minimizing their contribution to activity-dependent metabolism.
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