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Prof Parmjit Jat
Department of Neurodegenerative Disease, UCL Institute of Ne
Queen Square
London
WC1N 3BG
Tel: 020 7837 3973
Fax: 020 7676 2180
Appointment
  • Professor of Neurodegenerative Disease
  • Neurodegenerative Diseases
  • Institute of Neurology
  • Faculty of Brain Sciences
 
 
Research Groups
Research Themes
Research Summary
Normal somatic cells undergo a finite number of divisions and then cease dividing whereas cancer cells are able to proliferate indefinitely. This irreversible program of cell cycle arrest is triggered in response to a variety of intrinsic and extrinsic stimuli including alteration in telomere length and structure, DNA damage, physiological stresses and activation of certain oncogenes. It can lead to removal of defective and potentially cancerous cells from the proliferating pool thereby preventing neoplastic transformation and tumour development. It can also compromise tissue repair and regeneration and contribute to organismal ageing. The acquisition of an infinite proliferative potential is one of the six key events that are required for neoplastic transformation and one of the least understood since the underlying mechanism that controls cellular senescence and the signal transduction pathways involved are poorly understood. My research is aimed at identifying the underlying molecular basis for the finite proliferative life span and then if and how the key components are abrogated in cancer cells. We also aim to determine if these key components are conserved across species and in different cell types. Such components should represent novel, important and direct targets for both cancer and anti-ageing therapies.
Academic Background
1982 PhD Doctor of Philosophy Imperial College of Science, Technology and Medicine
1978 BS Bachelor of Science University of Bath
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