Help Desk: http://www.ucl.ac.uk/ras/portico/helpdesk
- Senior Lecturer
- Microbial Diseases
- Eastman Dental Institute
- Faculty of Medical Sciences
Adam graduated with an Honours degree in Applied Biology from Coventry University in 1995. In 1996 he began research at the Institute of Medical Sciences at the University of Aberdeen , investigating the molecular genetics of Tn5397, a conjugative transposon found in Clostridium difficile . He moved from Aberdeen to the Eastman Dental Institute in 1998 to complete his PhD.
Adam was appointed as a Research Fellow at the Eastman in 1999, to Lecturer in 2006 and to Senior Lecturer in 2012.
His research is concentrated on investigating the genetic basis for transferable antimicrobial resistance and virulence, predominantly in the Firmicutes. In addition he has a long standing interest in mobile genetic elements (MGEs) found throughout all domains of life. During his investigations new mobile genetic elements have been discovered and characterized. One family of mobile elements that Adam is particularly interested in is the "conjugative transposons" or "integrative conjugative elements". These common and highly promiscuous mobile elements can transfer antibiotic resistance genes from one species of bacteria to another.
Adam has also demonstrated transfer of conjugative transposons within oral biofilms. There is strong evidence that mobility of these elements may be stimulated by the presence of the antibiotic which they confer resistance to. To this end, his other main area of research is the investigation of the transcriptional and translational control mechanisms of these mobile elements.
Adam is currently involved in projects investigating the contribution of mobile genetic elements to, and the molecular basis of virulence of Clostridium difficile. Additionally he has projects investigating the emergence and persistence of antibiotic-resistant bacteria in humans, the molecular evolution of mobile genetic elements and their biological cost to the host cell, mobile genetic elements and resistance genes in microbial metagemones from human, animal and environmental samples and horizontal gene transfer in clinically important biofilms.
His group is currently funded by the European Union, the Schlumberger Foundation flagship program; Faculty for the Future, DEFRA, Commonwealth Scholarships, The Malaysian Government, The Eastman Foundation for Oral Research and Training (EFFORT) and UCL.
Ms Asyura Amdan (Biofilms, resistance and MGEs), Ms Enas Newire; (Antibiotic resistance and MGEs), Mr Ajijur Rahman (Metagenomics, resistance and HGT), Mr Liam Reynolds; (Metagenomic drug and drug resistance discovery), Mr Supathep Tansirichaiya (Resistance, MGEs & Metagenomics),
MSc / MSci / BSc students
Dr Nilesh Patel (MSc), Ms Sarika Shah (MSc).
Previous members of the group (and where they are now);
Dr Mohammed Al-Haroni (Tromsø University, Norway), Dr Amitabha Bhattacharjee; (Assam University, India), Dr Michael Brouwer (Central Veterinary Institute, Netherlands), Dr Lena Ciric; (UCL, UK), Dr Azmiza Jasni; (Universiti Putra, Malaysia), Dr Francesco Santoro; (Siena University, Italy), Dr Maria Amalie Seier-Petersen; (Technical University of Denmark & National Food Institute, Denmark), Dr Xiaobo Song; (Tromsø University, Norway), Dr Philip Warburton; (Anglia Ruskin University, UK), Dr Rachael Whalan, Dr Rachel Williams; (UCL, UK).
In Adam's lab there are currently projects available investigating various aspects of mobile genetic elements and antimicrobial resistance. Potential MSc and PhD students and individuals suitable for personal fellowships should contact Adam directly.
Tn number Registry; http://www.ucl.ac.uk/eastman/research/departments/microbial-diseases/tn
Mobile Genetic Elements; http://www.landesbioscience.com/journals/mge/
|2009||PGCLTHE||Postgraduate Certificate in Learning and Teaching in Higher Education||University College London|
|2002||PhD||Doctor of Philosophy||University of London|
|1995||BSc Hons||Bachelor of Science||Coventry University|