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Dr Laurent Bozec
(308) Sussex Wing
Biomaterials and Tissue Engineering, UCL Eastman Dental Inst
University College London, 256 Gr
London
WC1X 8LD
Tel: 020 3456 1188
Appointment
  • Senior Lecturer
  • Biomaterials & Tissue Eng
  • Eastman Dental Institute
  • Faculty of Medical Sciences
Biography

Laurent Bozec is the Head of Research and Director of the Eastman Centre for Postgraduate Research  at the Eastman Dental Institute, University College London. He is also a  Senior Lecturer in Biophysics and Nanometrology. The first part of his research portfolio involves the characterisation at the nanoscale of connective and mineralised tissues in view to improve both fundamental knowledge and diagnostic markers of diseases such as Scleroderma, Ehlers Danlos and Osteogenesis Imperfecta as well as ageing in collagen. Over the last 10 years, Dr Bozec has also been involved in the translation of SPM measurements to the field of conservation science. Since 2012, the technical portfolio of Dr Bozec has expanded as he has now taken the challenge to expand and democratise the use of Optical Coherence Tomography in the field of dentistry. Working with clinical colleagues at the UCL Eastman Dental Institute, he is interested in using this non-ionising technique for the diagnostics of rare dental conditions (Amelogenesis Imperfecta for example) as well as those hard to diagnose (enamel cracks and early carious demineralisation). Finally, being true to his physics background, Dr Bozec has been using large scale facilities such as Diamond UK and European Synchrotron Facility in Grenoble (France) to calibrate and provide further understanding in the nature of the scattering images provided by OCT. 

Research Summary

Investigating the mechano-biology of tissues at the nanoscale is paramount to establish not only the link between their forms and functions but also the inception of several diseases and disorders. With expertise in nanometrology and especially AFM & nanomechanics, Bozec’s group focusses primarily on “Mechano-Biology for Healthcare” in research fields related to ageing, connective and mineralised tissue disorders and finally bacteriology


Current Research topics in Bozec's group:

Over the years, Bozec's group has demonstrated leadership in AFM metrology at UCL focussing on the combination of imaging and mechanical approaches at the nano and mesoscale. Through a large number of collaborations with academic colleagues and industrial partners, we have been able to characterise a wide range of samples, ranging from single protein on surface to recellularised hydrogels and 15th Cent. parchments extracts for example.


1) Living-Probe

In this area of research, we are interested in functionalising AFM probe with "live-cell" in order to investigate the host-cell interactions. Using the AFM, we are routinely now functionalising probes with stem cells, fibroblasts, fungal and bacterial (gram+ and -) cells to measure their response to external stimuli as well as their adhesion with surfaces.  


2) Quantitative Nano-Histology 

In this area of research, we are pushing the boundaries of traditional histological assessment by combining it with other materials characterisation modalities, such as AFM based nanomechanics as part of an adjunct diagnostics setup.

Using our expertise in collagen characterisation, we are able to review tissues affected by rare syndromes such as Ehlers Danlos, Osteogenesis Imperfecta and Scleroderma. As part of this project we are also working on the impact of Advanced Glycation End products on the physical and mechanical properties of collagen tissues (human and model) at the nanoscale. 


3) Evaluation of Optical Coherence Tomography as a diagnostics tool for dentistry and its applications to dental anomalies and other defects.

In this area of research, we are keen to promote the use of OCT as part of clinical diagnostics for specific dental assaults and are developing both basics knowledge and metric to use this as an adjunct diagnostic approach.


4) Other projects:

  • Damage assessment of historical and modern parchment and cellulose based artefacts - Development of novel conservations strategies. 

  • Failures and bleaching of dental enamel: diagnostics and modelling.


As a keen researcher and mentor, I am always interested in new applications of nanometrology in the field of Materials Science and Regenerative Medicine and encourage potential PhD applicants to contact me directly.


Teaching Summary


Appointments
29-JUL-2015 Head of Research Eastman Dental Institute University College London, United Kingdom
01-OCT-2013 Senior Lecturer in Biophysics and Nanometrology Biomaterials & Tissue Engineering - Eastman Dental Institute University College London, United Kingdom
01-SEP-2007 Lecturer Biomaterials and Tissue Engineering Eastman Dental Institute - University College London, United Kingdom
01-SEP-2005 – 31-AUG-2007 Senior Research Fellow Medicine / London Centre for Nanotechnology University College London, United Kingdom
11-OCT-2002 – 31-AUG-2007 Research Fellow Medicine / London Centre for Nanotechnology University College London, United Kingdom
Academic Background
2003 PhD Doctor of Philosophy – Applied Physics University of Lancaster
1999 BSc Hons Bachelor of Science (Honours) – Applied Physics Nottingham Trent University
1997 HDIP Higher Diploma – Instrumental Techniques Universite de Rennes I
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