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Dr Laurent Bozec
(308) Sussex Wing
Biomaterials and Tissue Engineering, UCL Eastman Dental Inst
University College London, 256 Gr
London
WC1X 8LD
Tel: 020 3456 1188
Appointment
  • Senior Lecturer
  • Biomaterials & Tissue Eng
  • Eastman Dental Institute
  • Faculty of Medical Sciences
 
 
Biography

2013 - Present

 

Senior Lecturer in Biophysics and Nanometrology

(Eastman Dental Institute, University College London)

Departmental Graduate Tutor

(Eastman Dental Institute, University College London)


 

2007 - 2013


Lecturer in Biophysics and Tissue Engineering

(Eastman Dental Institute, University College London)

Departmental Graduate Tutor since  Nov 2011

(Eastman Dental Institute, University College London)







Research Summary

As a biophysicist with expertise in scanning probe microscopy, I am interested in understanding how the nanoscale properties of tissues shape their macroscale behaviour. One of my main focuses has been to introduce nanometrology to the filed of medical research and dentistry in particular. As such, I am driving now long-standing collaborations with various UCL groups (London Centre for Nanotechnology, Civil, Environmental and Geomatic Engineering and UCL Institute of Orthopaedics).

The first part of my research portfolio concerns the field of ageing research, and especially the understanding of ageing in connective tissue at the nanoscale. The second part of my research portfolio involves the utilisation of advanced probes for determination of the properties of tissues (such as collagen) and materials that will advance both biomarker identification and the development of biomaterials. Both these research areas are implicitly interlinked, making my overall research stands at the Life-Science interface as defined by RCUK and aligned to two of UCL Grand Challenges: Human Wellbeing and Global Health.

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#1 Collagen Biophysics


- Impact of Ageing on collagen biomechanical response at the fibrillar scale

- Characterisation of collagen in biopsy samples from patients diagnosed with Elhers Danlos, Osteogenesis Imperfecta, Fibrosis or Dentinogenesis Imperfecta.

- Fundamental understanding of the collagen fibrillar ultrastructure

- Mechanical impact of crosslinks on collagen fibril stability

- Denaturation pathways of collagen

Atomic Force Microscopy images of individuals collagen molecules (a) and aligned molecules (b)

#2 Tissue Engineering


- Increase of the mechanical properties of collagen scaffolds for use in tissue engineering.

- New routes to improve fibrillar alignement in collagen scaffold


#3 Stem Cells and surface implantology


- Understanding the binding adhesion properties of Stem cells to implants surface to increase cell differentiation using scanning probe microscopy.


#4 Collagen and conservation


Collagen has been used as a writing substrate for centuries and is the subject of great attention in pieces of art or ancient manuscripts that are subject to long term deterioration. I am extremely interested in assessing the damage present on the collagen and discovering new routes for long term conservation of those collagen based artifacts.


Teaching Summary


Appointments
01-OCT-2013 Senior Lecturer Biomaterials & Tissue Engineering - Eastman Dental Institute University College London, United Kingdom
01-SEP-2007 Lecturer Biomaterials and Tissue Engineering Eastman Dental Institute - University College London, United Kingdom
01-SEP-2005 – 31-AUG-2007 Senior Research Fellow Medicine / London Centre for Nanotechnology University College London, United Kingdom
11-OCT-2002 – 31-AUG-2007 Research Fellow Medicine / London Centre for Nanotechnology University College London, United Kingdom
Academic Background
1999 BSc Hons Bachelor of Science (Honours) Nottingham Trent University
1997 HDIP Higher Diploma Universite de Rennes I
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