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Appointment
  • Associate Professor
  • Dept of Biochemical Engineering
  • Faculty of Engineering Science
Biography

Andrea Rayat is Associate Professor in in Bioseparations and Downstream Processing at the Department of Biochemical Engineering at UCL. She is an associate member of the Institution of Chemical Engineers.


Andrea graduated from UCL with a PhD in Biochemical Engineering (2011). Her doctoral research focussed on the establishment of microscale bioprocessing platform for the evaluation of dead-end and cross-flow filtration operations and was used to study the impact of upstream conditions on filtration performance.


After her doctoral studies, Andrea worked at Biopharm Services, a company offering software technology solutions and technical consulting for biopharmaceutical manufacturing businesses. In her various roles as product engineer, product manager or bioprocess consultant, Andrea managed development updates for a process modeling software and created new functionalities for modelling and evaluating bioprocesses, equipment and facility operation, and their associated costs. She worked on projects which included manufacture siting, capacity planning and concept studies for new-build or brown-field capital projects. She developed business cases and value proposition of new bioprocess technologies through process and economic modelling.


Andrea re-joined UCL as HEFCE Senior Enterprise Fellow in Bioprocessing in 2014 where she worked on technology translation, knowledge exchange, and the establishment of the commercialisation pathway for the first-generation ultra scale-down devices. With Prof Gary Lye and Dr Alex Chatel, Andrea won a grant from the EPSRC Impact Acceleration Award (2016) for the establishment of commercial-ready USD devices. As a research staff, Andrea was part of the departmental committee for post-docs which organises seminars and workshops for their career development. One of these, Ideas to Impact workshop (2017), successfully obtained funding from the UCL Staff Development Programme. In 2018, she was appointed to an academic staff role as Lecturer in Bioseparations (Downstream Processing).


Andrea obtained her MSc in Chemical Engineering and Biochemical Engineering (cum laude) from Delft University of Technology in the Netherlands where she first specialised in downstream processing. She had her BSc in Chemical Engineering from the University of the Philippines in Laguna where she first experienced how to design, build and evaluate a unit operation for her undergraduate thesis.

Research Groups
Research Summary

Andrea’s research area in bioseparations covers filtration, centrifugation, other processes for cell harvest and primary recovery, and membrane filtration in downstream processing. She builds on the ultra scale-down (USD) approach, pioneered by UCL, which enables rapid understanding of bioprocesses and provides insights on robust manufacturing routes.

She continues to develop scale-down tools and apply high throughput techniques to evaluate such bioprocess performance, ultra scale-down membrane filtration for TFF evaluation, microscale TFF, and ultra scale-down centrifugation.

She is applying her expertise on downstream processing for different expression systems and biotech products such as mammalian cells to produce monoclonal antibodies and lentiviral vectors; and E.coli, yeast and other microbial systems for Fab fragments, enzymes or recombinant proteins. Most recently, this is applied to encapsulin production through a collaboration with VMIC (until 2021, this has now been taken on by an industry partner) led by colleague Dr Stefanie Frank.

Andrea has worked with Prof Mike Hoare, Davy Rowan and Biocatalysts Ltd. on a Knowledge Transfer Partnership funded by InnovateUK. This led to an IChemE Global Award 2020 in the Food and Drink Category and finalist in Biochemical Engineering Category. In 2021, the project was a Finalist in the Engineering Excellence Award in InnovateUK KTP Awards.

She currently collaborates with Dr Yasu Takeuchi at the Division of Infection and Immunity/NIBSC and industry partners through EngD collaborations via the Centre for Doctoral Training in Bioprocess Leadership. Other collaborators are Prof Martina Micheletti (scale-down upstream/downstream), Dr Qasim Rafiq (LV production), Prof Dan Bracewell (impact of bioprocesses on DSP), Prof Gary Lye (continuous processing) and Dr Nav Gill (strategic partnerships and MBI programme).

Teaching Summary
Andrea is Chair of the Departmental Teaching Committee and is Programme Director of the undergraduate programme in Biochemical Engineering (BEng/MEng). She works closely with the Departmental Tutor, Prof Martina Micheletti, and Deputy Head (Education), Prof Suzy Farid. She is a member of the departmental EDI and UGSSCC committees and the Faculty Education Committee at the Faculty of Engineering Sciences.

During the Covid-19 pandemic, Andrea was involved in the emergency response towards the end of Term 2 in 2019-2020 to move teaching delivery and assessments online. She has since served as the Covid-Mitigation Coordinator for the department and supported the Faculty Education Group for the 2020-21 planning and has led departmental efforts, together with the Education Leadership Team in the department of biochemical engineering, for the implementation of the Temporary Operating Model in 2020-21 and the move to Blended Learning for 2021-22 academic session.

Below are the modules taught by Andrea since 2015 (*current):
     BENG0006 Bioprocess Analysis (*module lead)  
     BENG0033 Bioprocess Synthesis and Process Mapping (*module tutor, previously module lead)

     BENG0007 Downstream Processing (*module tutor)
     BENG0101 Bioprocess Recovery and Purification (*module tutor)
     BENG0102 Downstream Processing for Engineers (*module tutor)
     
     BENG0034 Integrated Downstream Processing (*module tutor)  

     BENG0058 Downstream Processing: Primary Recovery (*module lead)
     MBI Downstream Processing: Primary Recovery (*module lead)
    
     BENG0077 Design of Experiments (module lead)

     MBI Design of Experiments (module lead)

    

     MBI Bioprocess Design and Economic Evaluation (module tutor)

     MBI Bioprocess Facility Design (module tutor)


     BENG0003 Introduction to Biochemical Engineering (module tutor)  

     MBI Quality by Design (module tutor)


     BENG0016 Design and Professional Skills II (guest speaker)
     BENG0044 Research Transferable Skills (guest speaker)    
     Advanced Data Analytics (ADA) in Bioprocessing (organiser/trainer)
     Regulatory Science for Advanced Cell and Gene Therapy - CPD course (guest speaker)
     Alliance4Tech (guest speaker)

Academic Background
2011   Doctor of Philosophy University College London
2004   Master of Science Technische Universiteit Delft
2001   Bachelor of Science University of the Philippines
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