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Dr Aleksandra Gentry-Maharaj
MRC CTU at UCL
90 High Holborn, 2nd Floor
London
WC1V 6LJ
Appointment
- Principal Research Fellow
- MRC Clinical Trials Unit at UCL
- Inst of Clinical Trials &Methodology
- Faculty of Pop Health Sciences
Biography
Joined the Gynaecological Cancer Research Centre as a Research Associate in 2003, first based at Barts and since April 2004 at the Institute for Women;'s Health, UCL. Since 2017, have taken on being the UKCTOCS Project Lead. Moved to the MRC CTU at UCL in August 2018. Current appointment as a Principal Research Fellow based at the Institute of Clinical Trials & Methodology and Institute for Women's Health.
Alex has presented her work at national and key international meetings (ESGO Istanbul 2005, IGCS Santa Monica 2006, ESGO Berlin 2007, IMS Madrid 2008, ESGO Nice 2015).
Over the past decade, Alex has been invited to give talks at a number of international meetings: Controversies of Ovarian Cancer Screening, University of Geneva (2009), 2nd Sino-Euro Experts Conference on Immune Biomarkers for Personalized Medicine in Oncology, Fudan University Shanghai Cancer Center, Shanghai (2015), Ovarian Cancer Academy, Cluj-Napoca, Romania (2015), Université catholique de Louvain UCLouvain, Brussels (2016), Multidisciplinary Approach to Gynecological Cancers conference, Krakow (2017).
Research Themes
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Main interest in ovarian and endometrial cancer screening. Alex is the Project Lead for the United Kingdom Collaborative Trial of Ovarian Cancer Screening (UKCTOCS), a randomised controlled trial involving 202,638 women from the UK assessing the mortality impact of screening. She has contributed to over 80 publications resulting from the trial, both from the core trial and all secondary studies. Since 2005, Alex has contributed to the International Ovarian Cancer Association Consortium (OCAC) looking at genetic predisposition to ovarian cancer and has contributed to over 100 publications in this field, including the first GWAS.
Alex has contributed to the area of biomarker discovery in ovarian cancer and led the papers exploring the value of HE4 in both screening and differential diagnosis. She has authored 5 chapters focussing on ovarian cancer biomarkers in the main gynaecological oncology textbooks and 5 reviews of ovarian cancer screening.
Alex has an interest in the menopause transition and the therapies that women use to alleviate their menopausal symptoms. Other interests include biomarker discovery for other cancers and cardiovascular disease.
Since 2020, expanded work trials in adjuvant setting in a role if Project Co-lead for Add-Aspirin and ICON8B.
Since 2022, CRUK ACED Co-Director of Research Domain Trials.
Teaching Summary
MSc Clinical Trials Programme Director
Co-lead for the following modules:
* Applying Clinical Trial Design Principles in Practice module on the MSc Clinical Trials
* Women's Cancers module on the iBSc Women's Heath
* Concept and Controversies of Women's Health module on the MSc Women's Health
* Breast and Reproductive Cancers on the MSc Reproductive Science and Women's Health
Education Webinar Lead for the International HundredK+ Cohorts Consortium (IHCC)
Academic Background
| 2002 | Doctor of Philosophy | King's College London | |
| 1998 | Master of Science | St George's Hospital Medical School | |
| 1996 | Bachelor Biomedical Science (Honours) | University of Westminster |
