I am interested in optimising deep brain stimulation treatment for Parkinson's Disease.  Currently, individualised therapy is difficult because we do not understand the underlying pathophysiology of individual symptoms in PD.  We concentrate on a subgroup of patients with severe disease undergoing surgery for deep brain stimulation (DBS) of the subthalamic nucleus (STN). These patients have the most acute need for individualised therapy and the surgical procedure itself provides aremarkable opportunity to explore the pathophysiological basis of phenotypic variation.
 

We have recently developed a study model which allows us to characterise the underlying dysfunctional brain networks in Parkinson's, based on simultaneous magnetoencephalographic (MEG) and intracranial electrode recordings in Parkinsonian patients. We are now investigating this further, by trying to identify how these brain networks relate to symptoms.